微导管接触性溶栓治疗静脉窦血栓形成
Clinical observation on treatment of venous sinus thrombosis with microcatheter contact thrombolysis
朱书敏 1孙冬 2刘煜敏 2梅斌 2王刚 3李华钢2
作者信息
- 1. 510405 广州中医药大学;蕲春县第二人民医院神经内科
- 2. 武汉大学中南医院神经内科
- 3. 佛山健翔骨伤医院针灸科
- 折叠
摘要
目的 分析留置微导管内接触性溶栓治疗颅内静脉窦血栓形成的疗效及安全性.方法 回顾性分析2021年11月 2023年11月武汉大学中南医院的13例确诊颅内静脉窦血栓形成经抗凝等药物治疗无效或重症患者的临床资料,采用中间导管取栓术联合留置微导管内接触性溶栓治疗颅内静脉窦血栓形成,并随访3个月,观察治疗效果.结果 13例患者中全部治愈好转,其中有8例患者术前意识障碍,出院时均意识清楚.13例患者出院时、术后第3个月美国国立卫生研究院卒中量表(National institute of health stroke scale,NIHSS)评分分别为2(0,4)、0(0,1)分,与术前16(8,35)分比较,均有明显差异(P＜0.01);改良Rankin量表(Modified Rankin scale,mRS)评分分别为1(0,2)、0(0,1)分,与术前5(4,5)分比较,均有明显差异(P＜0.01).结论 应用接触性溶栓治疗脑静脉窦血栓形成(Cerebral venous sinus thrombosis,CVST)有效,可改善患者神经功能,提高生活质量.
Abstract
Objective To analyze the recanalization rate,efficacy and safety of contact thrombolysis by indwelling microcatheter in the treatment of intracranial venous sinus thrombosis.Methods The clinical data of 13 patients with intracranial venous sinus thrombosis diagnosed in Zhongnan Hospital of Wuhan University from November 2021 to November 2023 were retrospectively analyzed.The intracranial venous sinus thrombo-sis was treated by intermediate catheter thrombectomy combined with contact thrombolysis by indwelling mi-crocatheter,and the treatment effect was observed for 3 months.Results All of the 13 patients were cured and improved.Among them,8 patients were conscious before operation,and they were all conscious when they were discharged.The scores of stroke scale(NIHSS)of 13 patients were 2(0,4)and 0(0,1)respec-tively at the time of discharge and 3 months after operation,which were statistically significant compared with the preoperative scores of 16(8,35)(P＜0.01).The scores of modified Rankin scale(mRS)were 1(0,2)and 0(0,1)respectively,which were statistically significant compared with 5(4,5)before operation(P＜0.01).Conclusion Contact thrombolysis is effective in treating CVST,which can improve patients'neurolog-ical function and quality of life.
关键词
静脉窦血栓形成/血管内介入/取栓治疗/接触性溶栓Key words
Venous sinus thrombosis/Intravascular intervention/Thrombolysis treatment/Contact thrombolysis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据