首页|Identification of TRPM7 channels in human intestinal interstitial cells of Cajal

Identification of TRPM7 channels in human intestinal interstitial cells of Cajal

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  • NETL
  • NSTL
  • Baishideng Publishing Group Inc
AIM: To investigate the characteristics of slow electrical waves and the presence of transient receptor potential melastatin-type 7 (TRPM7) in the human gastrointestinal (GI) tract.METHODS: Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue. Immunohisto-chemistry was used to identify TRPM7 channels in interstitial cells of Cajal (ICCs).RESULTS: The human GI tract generated slow electrical waves and had ICCs which functioned as pacemaker cells. Flufenamic acid, a nonselective cation channel blocker, and 2-APB (2-aminoethoxydiphenyl borate) and La~(3+), TRPM7 channel blockers, inhibited the slow waves. Also, TRPM7 channels were expressed in ICCs in human tissue.CONCLUSION: These results suggest that the human GI tract generates slow waves and that TRPM7 channels expressed in the ICCs may be involved in the generation of the slow waves.

electrophysiologyinterstitial cells of cajalTRPM cation channelstransient receptor potential melastatin-type 7 proteinhumangastrointestinal tract

Byung Joo Kim、Kyu Joo Park、Hyung Woo Kim、Seok Choi、Jae Yeoul Jun、In Youb Chang、Ju-Hong jeon、Insuk So、Seon Jeong Kim

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School of Korean Medicine, Pusan National University, Yangsan 626-870, South Korea

Department of Surgery, College of Medicine, Seoul National University, Seoul 110-799, South Korea

Department of Physiology, College of Medicine, Chosun University, Gwangju 501 -759, South Korea

Department of Anatomy, College of Medicine, Chosun University, Gwangju 501-759, South Korea

Center for Bio-Artificial Muscle and Department of Physiology, College of Medicine, Seoul National University, Seoul 110-799, South Korea

Center for Bio-Artificial Muscle and Department of Biomedical Engineering, Hanyang University, 17 Haengdang-Dong, Seongdong-gu, Seoul 133-791, South Korea

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2009

10.3748/wjg.15.5799

World Journal of Gastroenterology: WJG

World Journal of Gastroenterology: WJG

ISTP
ISSN：1007-9327
年,卷(期)：2009.15(46)
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