首页|Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions

Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions

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AIM: To evaluate the utility of diffusion-weighted imaging (DWI) in screening and differential diagnosis of benign and malignant focal hepatic lesions.METHODS: Magnetic resonance imaging (MRI) examinations were performed using the Signa Excite XI Twin Speed 1.5T system (GE Healthcare, Milwaukee, WI, USA). Seventy patients who had undergone MRI of the liver [29 hepatoceliular carcinomas (HCC), four cholangiocarcinomas, 34 metastatic liver cancers, 10 hemangiomas, and eight cysts] between April 2004 and August 2008 were retrospectively evaluated. Visualization of lesions, relative contrast ratio (RCR), and apparent diffusion coefficient (ADC) were compared between benign and malignant lesions on DWI. Su-perparamagnetic iron oxide (SPIO) was administered to 59 patients, and RCR was compared pre- and post-administration.RESULTS: DWI showed higher contrast between malignant lesions (especially in multiple small metastatic cancers) and surrounding liver parenchyma than did contrast-enhanced computed tomography. ADCs (mean ± SD × 10~3 mm~2/s) were significantly lower (P < 0.05) in malignant lesions (HCC: 1.31 ± 0.28 and liver metastasis: 1.11 ± 0.22) and were significantly higher in benign lesions (hemangioma: 1.84 ± 0.37 and cyst: 2.61 ± 0.45) than in the surrounding hepatic tissues. RCR between malignant lesions and surrounding hepatic tissues significantly improved after SPIO administration, but RCRs in benign lesions were not improved.CONCLUSION: DWI is a simple and sensitive method for screening focal hepatic lesions and is useful for differential diagnosis.

hepatic tumorliver imagingmagnetic resonance imagingdiffusion-weighted imagingapparent diffusion coefficient

Naoto Koike、Akihiro Cho、Katsuhiro Nasu、Kazuhiko Seto、Shigeyuki Nagaya、Yuji Ohshima、Nobuhiro Ohkohchi

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Department of Surgery, Seirei Sakura Citizen Hospital, 2-36-2 Ebaradai, Sakura, Chiba 285-3765, Japan

Department of Surgery, Chiba Cancer Center, 666-2 Nitona, Chuhohku, Chiba 260-8717, Japan

Department of Radiology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan

Department of Radiology, Seirei Sakura Citizen Hospital, 2-36-2 Ebaradai, Sakura, Chiba 285-8765, Japan

Department of Radiology, Seirei Mikatabara Hospital, 3453 Mikatabara, Kitaku, Hamamatsu, Shizuoka 433-8558,Japan

Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan

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2009

10.3748/wjg.15.5805

World Journal of Gastroenterology: WJG

World Journal of Gastroenterology: WJG

ISTP
ISSN：1007-9327
年,卷(期)：2009.15(46)
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