Pro-oxidative, genotoxic and cytotoxic properties of uranyl ions

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Elsevier

外文摘要：It is demonstrated that hydroxyl radicals and hydrogen peroxide are formed under the action of uranyl ions in aqueous solutions containing no reducing agents. In the presence of uranyl ions, formation of 8-oxoguanine in DNA and long-lived protein radicals are observed in vitro. It is shown that the pro-oxidant properties of uranyl at micromolar concentrations mostly result from the physico-chemical nature of the compound rather than its radioactive decay. Uranyl ions lead to damage in DNA and proteins causing death of HEp-2 cells by necrotic pathway. It is revealed that the uranyl ions enhance radiation-induced oxidative stress and significantly increase a death rate of mice exposed to sublethal doses of X-rays.

外文关键词：

Uranyl ionsReactive oxygen speciesLong-lived protein radicals8-oxoguanine

作者：

S.A. Garmash、V.S. Smimova、O.E. Karp、A.M. Usacheva、A.V. Berezhnov、V.E. Ivanov、A.V. Chernikov、V.I. Bruskov、S.V. Gudkov

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作者单位：

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia,Pushchino State University, Pushchino, Moscow Region 142290, Russia

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia

Institute of Cell Biophysics, Russian Academy of Sciences, 3 Institutskaya Street, Pushchino, Moscow Region 142290, Russia

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia,Pushchino State University, Pushchino, Moscow Region 142290, Russia,Institute of Cell Biophysics, Russian Academy of Sciences, 3 Institutskaya Street, Pushchino, Moscow Region 142290, Russia

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出版年：

2014

DOI：

10.1016/j.jenvrad.2012.12.009

Journal of environmental radioactivity

ISSN：0265-931X

年,卷(期)：2014.127(Jan.)

被引量23
参考文献量45