首页|Increased Production of Coenzyme Q_(10) from Genetic Engineered Rhodobacter sphaeroides Overexpressing UbiG
Increased Production of Coenzyme Q_(10) from Genetic Engineered Rhodobacter sphaeroides Overexpressing UbiG
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NETL
NSTL
The aim of this study was to increase the Coenzyme Q_(10) (CoQ_(10)) yield from Rhodobacter sphaeroides via genetic engineering pathway. CoQ_(10) plays important roles in many biological processes and has been proven to be effective in the treatment of many diseases. In the present study, the ubiG gene located in CoQ_(10) biosynthesis pathway was effectively overexpressed in Rb. sphaeroides to increase CoQ_(10) production. The growth of host cells was slightly influenced by overexpressing ubiG. The crude CoQ_(10) production was enhanced by 58.31% compared to that from the control. The ubiG mRNA level was significantly increased compared to the wild type harboring empty vector as measured by qRT-PCR. Moreover, the crude CoQ_(10) exhibited strong anti-oxidant activity as measured in vivo by zone of inhibition assay.
NETL
NSTL
