首页|Subchronic exposure to fenpyroximate causes multiorgan toxicity in Wistar rats by disrupting lipid profile, inducing oxidative stress and DNA damage
Subchronic exposure to fenpyroximate causes multiorgan toxicity in Wistar rats by disrupting lipid profile, inducing oxidative stress and DNA damage
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NETL
NSTL
Taylor & Francis
Background: Fenpyroximate (FEN) is an acaricide that inhibits the complex I of the mitochondrial respiratory chain in mites. Data concerning mammalian toxicity of this acaricide are limited; thus the aim of this work was to explore FEN toxicity on Wistar rats, particularly on cardiac, pulmonary, and splenic tissues and in bone marrow cells. Methods: rats were treated orally with FEN at 1, 2, 4, and 8mg/Kg bw for 28days. After treatment, we analyzed lipid profile, oxidative stress and DNA damage in rat tissues. Results: FEN exposure increased creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH) activities, elevated total cholesterol (T-CHOL), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) concentrations, while decreasing high-density lipoprotein cholesterol (HDL-C). It inhibited acetylcholinesterase (AChE) activity, enhanced lipid peroxidation, protein oxidation, and modulated antioxidant enzymes activities (superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase). Comet assay indicated that FEN induced a dose-dependent DNA damage, contrasting with the micronucleus test showing no micronuclei formation. Nonetheless, FEN exhibited cytotoxicity to bone marrow cells, as evidenced by a reduction in the number of immature erythrocytes among total cells. Conclusion: FEN appears to carry out its genotoxic and cytotoxic activities most likely through an indirect pathway that involves oxidative stress.
Laboratory of Research on Biologically Compatible Compounds, LR01SE17, University of Monastir, Faculty of Dental Medicine, Monastir, Tunisia||Faculty of Science of Gafsa, University of Gafsa, Gafsa, Tunisia
Laboratory of Research on Biologically Compatible Compounds, LR01SE17, University of Monastir, Faculty of Dental Medicine, Monastir, Tunisia
NETL
NSTL
Taylor & Francis
