首页|Phoenix dactylifera, L. seed oil alleviates Bleomycin-induced pulmonary fibrosis and oxidative stress in Wistar rats

Phoenix dactylifera, L. seed oil alleviates Bleomycin-induced pulmonary fibrosis and oxidative stress in Wistar rats

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Objective: Idiopathic pulmonary fibrosis (IPF) is the most serious form of interstitial lung disease. We aimed to investigate the effect of Phoenix dactylifera, L seed oil (DSO) on a murine model of IPF induced by bleomycin (BLM). Methods: Male Wistar rats were treated with a single intra-tracheal injection of BLM (4 mg/kg) and a daily intraperitoneal injection of DSO (75, 150 and 300 mg/kg) for 4weeks. Results: Our phytochemical results showed that DSO has an important antioxidant activity with a high content of polyphenols and flavonoids. High-Performance Liquid Chromatography (HPLC) and Gas chromatography/mass spectrometry (GC-MS) analysis revealed a high amount of oleic and lauric acids and a large quantity of vitamins. Histological examination showed a significant reduction in fibrosis score and collagen bands in the group of rats treated with 75mg/kg of DSO compared to the BLM group. DSO (75 mg/kg) reversed also the increase in catalase and malondialdehyde (MDA) levels while higher doses (150 and 300 mg/kg) are ineffective against the deleterious effects of BLM. We revealed also that DSO has no renal or hepatic cytotoxic effects. Conclusion: DSO can play antioxidant and antifibrotic effects on rat models of pulmonary fibrosis at the lowest dose administered.

Lung fibrosisoxidative stressdate seed oilvitaminsfatty acids

Sana Bahri、Raed Abdennabi、Asma Chaker、Afef Nahdi、Amine Elgheryeni、Mona Mlika、Saloua Jameleddine

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Laboratory of Physiology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia||Laboratory of Physiopathology, Food and Biomolecules (LR-17-ES-03), Technology Center of Sidi Thabet, University of Manouba, Tunis, Tunisia

Laboratory of Plant Biotechnology, Faculty of Science, University of Sfax, Sfax, Tunisia

Functional Exploration and Physiotherapy Department, Abderhaman Mami Hospital, Ariana, Tunisia

Research Unit n° 17/ES/13, Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia

Faculty of Physiology, University of Gabes, Gabes, Tunisia

Laboratory of Anatomy and Pathology, Abderhaman Mami Hospital, Ariana, Tunisia

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2024

10.1080/1354750X.2024.2311178

Biomarkers

Biomarkers

SCI
ISSN：1354-750X
年,卷(期)：2024.29(1/8)
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