首页|Assessing angiogenesis factors as prognostic biomarkers in breast cancer patients and their association with clinicopathological factors

Assessing angiogenesis factors as prognostic biomarkers in breast cancer patients and their association with clinicopathological factors

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  • NETL
  • NSTL
  • Taylor & Francis
Introduction: Angiogenesis is fundamental for tumor growth and metastasis across many solid malignancies. Considerable interest has focused on the molecular regulation of tumor angiogenesis as a means to predict disease outcomes and guide therapeutic decisions. Methods: In the present study, we investigated the prognostic value of transforming growth factor beta (TGF-β), epidermal growth factor (EGF), fibroblast growth factor (FGF), delta-like ligand 4 (DLL4), and vascular endothelial growth factor (VEGF) in the serum of 120 women diagnosed with breast cancer using ELISA as well as examined their associations with clinical parameters and the outcome of the disease. Results: Our results demonstrated that the serum concentration of TGF-β and EGF were remarkably higher in patients with higher tumor size, end stages of the disease, and positive lymph node involvement compared to patients with lower tumor size, early stages of the disease, and negative lymph node involvement. In addition, we found a significant correlation between the serum concentration of VEGF and the level of EGF, FGF, and DLL4 in patients with breast cancer. Furthermore, both univariate and multivariate analyses showed that TGF-β and EGF can be used as end-stage predictors. Discussion/Conclusion: Based on our findings, increasing the level of angiogenesis factors is significantly associated with higher tumor size and late stages of the disease in patients with breast cancer. Moreover, measuring the level of angiogenesis factors could lead to better prediction of disease outcomes and choosing the best treatments for patients.

Breast cancerVEGFFGFEGFTGF-βDLL4

Tannaz Abbasi-Dokht、Farhad Malek、Nahid Nafissi、Maryam Mohammadlou、Maryam Sheikh、Sedigheh Akbari、Mohammad Hossein Zargaran、Rasoul Baharlou

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Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran||Department of Immunology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

Department of Internal Medicine, Kosar Hospital, Semnan University of Medical Sciences, Semnan, Iran

Department of Breast, Rasoul Akram Hospital Clinical Research Development Center (RCRDC), Iran University of Medical Sciences, Tehran, Iran

2024

10.1080/1354750X.2024.2309541

Biomarkers

Biomarkers

SCI
ISSN：1354-750X
年,卷(期)：2024.29(1/8)
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