首页|Short-term and lagged effects of ambient air pollutants on CVD hospitalization: A two-decade population-based study in Tehran

Short-term and lagged effects of ambient air pollutants on CVD hospitalization: A two-decade population-based study in Tehran

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  • NETL
  • NSTL
  • Elsevier
Objectives: To evaluate the relationship between short-term exposure to ambient air pollutants and cardiovascular disease (CVD) hospitalizations. Methods: A time-series analysis was conducted using data from the Tehran Lipid and Glucose Study cohort of 3454 residents (1880 women) aged 50-70 from District 13 of Tehran. Follow-up data from January 1999 to March 2018 were analyzed. Daily mean temperatures and air pollution levels (CO, O3, PM10, NO2, and SO2) were recorded, and distributed lag non-linear models (DLNMs) assessed the lagged effects on outcome. Results: Over a median follow-up of 14.7 years, 2200 CVD hospitalizations occurred among 3454 participants (mean age 58.7 years, women = 1880). Among the general population, the DLNM models indicated that PM10 concentrations at 73 mu g/m3 was associated with a 12 % increased risk of the outcome, with an RR of 1.12 (95 % CI: 1.01-1.24), and higher PM10 levels corresponded to increasing RRs. PM10 indicated a short-term exposure effect at 1-day lag on the outcome risk. SO2 concentrations reached significance at 24 mu g/m3, with an RR of 1.06 (95 % CI: 1.04-1.07); the effect persisted up to 65 mu g/m3, with an increased risk of the outcome observed at a 6day lag. CO showed the highest RR of 1.92 (95 % CI: 1.65-2.23) for the concentration of 5 mg/m3. Exposure to CO was linked to an increased risk of the outcome with a 1-day lag. Sex as well as presence of metabolic syndrome and CKD did not modify the association between air pollutants with the outcome. Conclusions: Short-term exposure to PM10, SO2 and CO significantly increased risk of CVD hospitalization.

Ambient air pollutionCardiovascular diseaseHospitalizationLongitudinal studyTLGSCASE-CROSSOVER ANALYSISCARDIOVASCULAR-DISEASEMYOCARDIAL-INFARCTIONPARTICULATE MATTERMETABOLIC SYNDROMESULFUR-DIOXIDEGLOBAL BURDENPOLLUTIONMORTALITYEXPOSURE

Khajavi, Alireza、Ebrahimi, Navid、Masrouri, Soroush、Hasheminia, Mitra、Azizi, Fereidoun、Khalili, Davood、Hadaegh, Farzad

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Shahid Beheshti Univ Med Sci

2025

10.1016/j.ijheh.2025.114573

International journal of hygiene and environmental health

International journal of hygiene and environmental health

SCI
ISSN：1438-4639
年,卷(期)：2025.266(May)
  • 51