首页|Impact of NF-κB Signaling and Sirtuin-1 Protein for Targeted Inflammatory Intervention

Impact of NF-κB Signaling and Sirtuin-1 Protein for Targeted Inflammatory Intervention

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  • NETL
  • NSTL
  • Bentham Science Publ Ltd
This detailed review disclosed the NF-kB pro-inflammatory gen's activity regulation and explored the therapeutic significance, activation, and inhibition. This study uncovers the structural intricacies of the NF-kB proteins and highlights the key role of SIRT1 in NF-kB signaling pathway regulation. Particularly the Rel Homology Domain (RHD), elucidating interactions and the regulatory mechanisms involving inhibitory proteins like 1κB and p100 within the NF-κB signaling cascade. Disruption of the pathway is important in uncontrolled inflammation and immune disorders. This study extensively describes the role connections of canonical and non-canonical signaling pathways of NF-κB with inflammatory and cellular responses. SIRT1 belongs to the class Ⅲ histone deacetylase, via RelA/p65 deacetylation, it regulates the activity of NF-κB, closely linked with the NAD+/NADH cellular ratio, influencing stress responses, aging processes, gene regulation, and metabolic pathways. This detailed study reveals SIRT1 as a crucial avenue for uncovering the role of imbalanced NF-κB in diabetes, obesity, and atherosclerosis. This study provides valuable knowledge about the therapeutic targets of inflammatory disorders.

Auto-immuneNF-κBSirtunin-1inflammationobesitymetabolic disordersignaling pathways

Sagar Das、Tuhin Mukherjee、Satyajit Mohanty、Nikita Nayak、Payel Mal、Sumel Ashique、Radheshyam Pal、Sourav Mohanto、Himanshu Sharma

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Department of Pharmacology, Karnataka College of Pharmacy, Bengaluru, Karnataka, 560064, India

Division of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India

School of Pharmaceutical and Population Health Informatics, DIT University, Makkawala, Dehradun, 248009, Uttarakhand, India

Department of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences & Research, Durgapur, 713212, West Bengal, India

Department of Pharmaceutical Sciences, Pandaveswar School of Pharmacy, Pandaveswar, West Bengal, 713346, India

Department of Pharmaceutics, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka, 575018, India

Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, (UP)-244001, India

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2025

10.2174/0113892010301469240409082212

Current pharmaceutical biotechnology

Current pharmaceutical biotechnology

SCI
ISSN：1389-2010
年,卷(期)：2025.26(8)
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