Aggregation-Induced NIR-Ⅱ Emission Luminogens Integrated into Cu~(2+)-Phenolic Nanoparticles for Mild-Temperature Photothermal Eradication of Bacterial Biofilms

Haojie Chen ¹Xinyue Yang ²Yongcheng Chen ¹Fang Liu ¹Dingyuan Yan ³Yutong Li ¹Guogang Shan ²Qiuxia Luo ³Hang Song ⁴Dong Wang ³Qiao Jin¹

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作者信息

1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, P. R. China
2. Institute of Functional Material Chemistry, Northeast Normal University, Changchun, Jilin, P. R. China
3. Center for AIE Research, Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Material Science and Engineering, Shenzhen University, Shenzhen, P. R. China
4. Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China||Beijing Key Laboratory of Fundus Diseases Intelligent Diagnosis & Drug/Device Development and Translation, Beijing, P. R. China
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Abstract

Drug-resistant biofilm infections pose a critical global health challenge, demanding innovative therapies. We developed a butterfly-shaped aggregation-induced emission luminogen (AIEgen), 4TPE-DTB, as a potent photothermal agent for biofilm eradication. Encapsulating 4TPE-DTB into pH-responsive Cu~(2+)-tannic acid nanoparticles (CTNPs) yielded a synergistic platform (DTB@CTNPs) combining mild photothermal therapy (PTT) with controlled Cu~(2+) release. DTB@CTNPs exhibited strong bacterial membrane adhesion and acid-triggered Cu~(2+) release, specifically targeting biofilm microenvironments. 4TPE-DTB enabled NIR-Ⅱ imaging-guided therapy, permitting real-time infection localization while generating localized hyperthermia under 808 nm irradiation. The photothermal effect disrupted bacterial membranes, enhancing intracellular Cu~(2+) influx and antibacterial efficacy. In vitro, DTB@ CTNPs eradicated mature biofilms at low doses. In vivo, they effectively treated methicillin-resistant Staphylococcus aureus (MRSA) abscesses and Pseudomonas aeruginosa keratitis, demonstrating superior antibiofilm performance. This work presents a multifunctional nanoplatform synergizing AIEgen-mediated mild PTT and Cu~(2+) delivery, achieving potent bactericidal activity with minimal cytotoxicity. The strategy addresses a pressing unmet need in combating drug-resistant biofilm infections.

Key words

aggregation-induced emission/biofilm eradication/metal-phenolic network/mild photothermal therapy/NIR-Ⅱ fluorescence emission

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出版年

2026

Advanced materials for optics and electronics

ISSN：1616-301X

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