首页|Comparative analysis of the efficacy and safety of herbal decoction CheReCunJin alone and combined with hydroxychloroquine for treating primary Sjo euro gren's syndrome: A randomized controlled trial
Comparative analysis of the efficacy and safety of herbal decoction CheReCunJin alone and combined with hydroxychloroquine for treating primary Sjo euro gren's syndrome: A randomized controlled trial
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NSTL
Elsevier
Introduction: There is currently no established effective treatment for primary Sjo euro gren's syndrome (pSS). Tra-ditional Chinese Medicine (TCM) is widely used in China and is reported to improve patient symptoms. This study compare the clinical efficacy and safety of herbal decoction CheReCunJin alone and combined with hydroxychloroquine for the treatment of pSS.Methods: Seventy pSS patients without visceral involvement were randomly assigned in equal numbers to oral administration of CheReCunJin decoction only (group 1) or CheReCunJin decoction combined with hydroxychloroquine (group 2), Efficacy was evaluated after 3 months of treatment by the TCM syndrome and total effectiveness scores, European League Against Rheumatism (EULAR) Sjo euro gren's Syndrome Patient Reported Index (ESSPRI), and Sjo euro gren's Syndrome Disease Activity Index (ESSDAI), Schirmer's test, erythro-cyte sedimentation rate (ESR), C-reactive protein (CRP), and immunoglobulin G (IgG) levels. Safety was assessed.Results: There were no differences in the baseline characteristics of the two groups. Compared with baseline values, the TCM syndrome, ESSPRI and ESSDAI scores, ESR, CRP, and Schirmer's test results improved signifi-cantly in both groups after treatment (p < 0.05). There was no significant difference in the TCM syndrome total effectiveness rate between the two groups (p = 0.31). Between-group differences in the changes in ESSPRI, ESSDAI, ESR, CRP, Schirmer's test, and IgG after treatment were not significant (all p> 0.05). Adverse reactions were reported in 5.88% of group 1 and 3.33% of group 2 participants (p = 0.83).Conclusion: CheReCunJin decoction alone was effective and safe for the treatment of pSS. Trial registration: Chinese Clinical Trial Registry: ChiCTR1800016471 (c) 2021 Elsevier Inc. All rights reserved.
Primary Sjo ? gren?s syndromeCheReCunJin decoctionTraditional Chinese medicinePRIMARY SJOGRENS-SYNDROMETRADITIONAL CHINESE MEDICINETOTAL GLUCOSIDESMETHOTREXATELEFLUNOMIDECONSENSUSPEONY
Shao, Qin、Jin, Liang、Li, Chengyin、Wang, Jing、Wang, Miao、Wang, Qin、Wu, Bin
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Chongqing Hosp Tradit Chinese Med
Chongqing Key Lab Tradit Chinese Med Prevent & Tre
NSTL
Elsevier
