首页|Circulating Tumor DMA In Adults With Glioma: A Systematic Review and Meta-Analysls of Blomarker Performance
Circulating Tumor DMA In Adults With Glioma: A Systematic Review and Meta-Analysls of Blomarker Performance
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NSTL
BACKGROUND: Circulating tumor DNA (ctDNA) has emerged as a promising noninvasive biomarker to capture tumor genetics in patients with brain tumors。 Research into its clinical utility， however， has not been standardized because the sensitivity and specificity of ctDNA remain undefined。 OBJECTIVE: To (1) review the primary literature about ctDNA in adults with glioma to compare the sensitivity and specificity of ctDNA in the cerebrospinal fluid vs the plasma and (2) to evaluate the effect of tumor grade on detection of ctDNA。 METHODS; PRISMA-guided systematic review and meta-analysis was performed using published studies that assessed ctDNA in either plasma or cerebrospinal fluid among adult patients with confirmed glioma。 Summary receiver operating characteristic curves were generated using the Rucker-Schumacher method， and area under the curve (AUC) was calculated。
NSTL
