首页|Phenanthridine based rapid "turn-on" fluorescent sensor for selective detection of Th4+ ion and its real-time application
Phenanthridine based rapid "turn-on" fluorescent sensor for selective detection of Th4+ ion and its real-time application
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NSTL
Elsevier
A new and highly sensitive and selective phenanthridine based sensor, 9-(7,8,13,14-tetrahydrodibenzo[a, i]phenanthridin-5-yl)benzo[h]quinolin-10-ol (PHBQ), was developed for the fluorescent "turn-on"detec-tion of Th4+ ion in acetonitrile: water (8:2) medium. The fluorescence intensity of PHBQ diminished in the region of pH 1 to 3 and could be recovered by adjusting the pH to above 4. The sensor PHBQ showed dis-tinct spectral changes in response to Th4+ ion over other competitive metal ions. The fluorescence displayed good linearity with the Th4+ concentration in the equivalence of 0-0.5 equivalents. The detection limit was calculated to be as low as 99 nM, which was less than that of previously reported sen-sors. The recognizing mechanism of PHBQ towards Th4+ was investigated in detail using HR-MS, NMR, and IR spectroscopy. The economically viable Whatman filter paper was fabricated with PHBQ to develop a paper-based fluorescence kit to detect the Th4+ in an aqueous medium efficiently. Furthermore, the application of sensor ligand in fluorescence imaging was studied in E-coli cells due to its minimal cyto-toxicity and good optical properties. The obtained data suggest that the ligand PHBQ can be used as a fluorescent sensor for tracking Th4+ in multiple applications. (C) 2021 Elsevier B.V. All rights reserved.
NSTL
Elsevier
