首页|Phosphatases of regenerating liver are key regulators of metabolism in cancer cells – role of Serine/Glycine metabolism
Phosphatases of regenerating liver are key regulators of metabolism in cancer cells – role of Serine/Glycine metabolism
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NSTL
Lippincott Williams & Wilkins
Phosphatases of regenerating liver (PRL) are dual-specificity phosphatases and comprise three members， PRL-1， -2 and -3。 Despite the importance of PRLs as oncoproteins， there is no consensus function for this family of phosphatases。 In the current review paper， we summarize recent findings on the role of PRLs in metabolic regulation。 Reprogramming of cellular metabolism is a cancer hallmark。 Glucose is the major source of energy in cells。 Glucose metabolism occurs through the glycolysis and can continue through the pathways such as serine synthesis pathway or the tricarboxylic acid cycle (TCA)。 Magnesium (Mg2+)， the second most abundant cation in cells， plays an essential role in energy production by acting as a cofactor for most enzymes involved in glycolysis and in TCA。 Recent findings have shown that the PRL family has a role in metabolic reprogramming mediated by (1) Mg2+ homeostasis， (2) shifting the energy source preference to glucose consumption and fueling serine/glycine pathway and (3) regulating PI3 kinase/Mammalian target of rapamycin complex。 Both the phosphatase and nonphosphatase activity of PRLs appear to be important for its oncogenic role。 The PRL family contributes to the metabolic plasticity of cancer cells and， thereby， allows cancer cells to meet the high metabolic demands required for cell proliferation。
Esten N.,Vandsemb、Magne,B?rset、Pegah,Abdollahi
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Center for Myeloma Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and
NSTL
Lippincott Williams & Wilkins
