首页|Turn-off fluorescence of nitrogen and sulfur carbon quantum dots as effective fluorescent probes for determination of imatinib. Application to biological fluids
Turn-off fluorescence of nitrogen and sulfur carbon quantum dots as effective fluorescent probes for determination of imatinib. Application to biological fluids
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NSTL
Elsevier
Nitrogen and sulfur carbon quantum dots(N,S-CQDs) as effective fluorescent nanoprobes were synthe-sized through one-step-hydrothermal method using thiosemicarbazide (as nitrogen and sulfur source) and citric acid (as carbon source). The highly fluorescent N,S-CQDs were subjected to various character-ization techniques. The fluorescence of the synthesized N,S-CQDs is characterized by maximum fluores-cence emission at 415 nm after excitation at 345 nm and a high quantum yield of 0.58. The native N,S-CQDs fluorescence is quantitatively quenched upon addition of imatinib (IMA), so they are used for its spectrofluorimetric determination in its pharmaceutical formulations and biological fluids. Under optimal conditions, N,S-CQDs exhibited a "turn-off" fluorescence response to IMA over the range of 1.0 to 15.0 mg/mL with a limit of quantification of 0.42 mg/mL anda lower detection limit of 0.14 mg/mL. Stern-Volmer equation was used to study the mechanism of quenching and it was found to occur through static quenching mechanism. The method was extended to the in-vitro determination of the drug in spiked human urine and plasma samples and the percent recoveries were satisfactory.(c) 2022 Elsevier B.V. All rights reserved.
NSTL
Elsevier
