首页|A ratiometric fluorescent probe for sensing hypochlorite in physiological saline, bovine serum albumin and fetal bovine/calf serum
A ratiometric fluorescent probe for sensing hypochlorite in physiological saline, bovine serum albumin and fetal bovine/calf serum
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NSTL
Elsevier
HClO/ClO-, as one of important reactive oxygen species, is a highly reactive unavoidable by-product generated from normal cell metabolism. In recent years, efficient method for detectiing HClO/ClO- is of great important to research its pathological or physiological function in bio-systems. In this work, we have constructed a fluorescent probe (P-Hc) with ratiometric signal for sensing HClO/ClO- in aqueous solution, physiological saline and different serums based on 2-(benzo[d]thiazol-2-yl)phenol dye. The structure of P-Hc was characterized by NMR and HRMS spectrum. The sensing mechanism has also been verified by H-1 NMR spectrum. The P-Hc displays good sensitivity and selectivity for HClO/ClO- with a limit of detection (LOD) of 2.03 x 10(-6) M. Furthermore, P-Hc has been applied for sensing HClO/ClO- in physiological saline and different serums. Thus, P-Hc may provide a novel method for ratiometric fluorescent sensing HClO/ClO- in bio-samples. (C) 2021 Elsevier B.V. All rights reserved.
NSTL
Elsevier
