首页|Electrochemical sensors for sulfamethoxazole detection based on graphene oxide/graphene layered composite on indium tin oxide substrate

Electrochemical sensors for sulfamethoxazole detection based on graphene oxide/graphene layered composite on indium tin oxide substrate

扫码查看
原文链接
  • NSTL
  • Elsevier
Background: Sulfamethoxazole (SMX) can produce many side effects in the human body and several hematological abnormalities. Therefore, the analytical determination of SMX in pharmaceutical formulations and biological fluids is essential. Methods: A biocompatible composite of graphene oxide/graphene (GO/G) layered structure was synthesized to develop electrochemical biosensors for SMX detection. Two layers of single-layer graphene grown by chemical vapor deposition were stacked and annealed to form bilayer graphene (BLG). The BLG was modified by a low-damage plasma treatment-atomic layer oxidation. The top graphene layer was modified to graphene oxide, while the bottom graphene layer was conserved to safeguard its conductive properties and form a layered composite on an indium tin oxide (ITO) substrate. Significant findings: The GO/G layered composite on the ITO glass substrate, plasma-treated for 15 min exhibited optimized redox properties, with a relatively low charge-transfer resistance. At pH 6, the relationship between the oxidation peak current and the SMX concentration (0.1-50 mu M) was linear with a sensitivity of 0.262 mu A/mu M. With the addition of cetylpyridinium chloride, the sensing performance of the GO/G-based electrochemical sensor was ameliorated to 0.529 mu A/mu M. The GO/G electrode also exhibited high selectivity and stability to SMX. (C) 2021 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

Graphene oxide/grapheneLayered compositeElectrochemical sensorLow-damage plasmaSulfamethoxazoleAtomic layer oxidationCARBON-PASTE ELECTRODEPULSE VOLTAMMETRIC DETERMINATIONELECTROANALYTICAL DETERMINATIONADSORPTIONOXIDATIONSULFONAMIDESNANOTUBESNANOCOMPOSITENANOPARTICLESTRIMETHOPRIM

Yeh, Ssu-Hsien、Huang, Min-Shin、Huang, Chi-Hsien

展开 >

Ming Chi Univ Technol

2022

10.1016/j.jtice.2021.11.022

Journal of the Taiwan Institute of Chemical Engineers

Journal of the Taiwan Institute of Chemical Engineers

EISCI
ISSN：1876-1070
年,卷(期)：2022.131
  • 17
  • 65