首页|Folic acid functionalized molybdenum oxide quantum dots for the detection of Cu2+ ion and alkaline phosphatase via fluorescence turn off-on mechanism
Folic acid functionalized molybdenum oxide quantum dots for the detection of Cu2+ ion and alkaline phosphatase via fluorescence turn off-on mechanism
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NSTL
Elsevier
The assay of alkaline phosphatase (ALP) plays a key role in the diagnosis of various diseases. Herein, folic acid functionalized molybdenum oxide quantum dots (FA-MoOx QDs) are explored as fluorescence "turn-off and on" probes for assaying of Cu2+ ion and ALP, respectively. This fluorescence sensing strategy was based on the quenching of emission peak of FA-MoOx QDs at 445 nm by Cu2+ ion, followed by restoring of emission peak selectively with ALP. Based on the quenching and restoring of FA-MoOx QDs emission intensity, quantitative assay was developed for the detection of Cu2+ ion (0.20 - 500 mu M) and ALP (0.06 - 150 U/L) with detection limits of 29 nM and 0.026 U/L, respectively. The developed FA-MoOx QDs-based fluorescence ''turn- off and on" strategy exhibited satisfactory results for assaying of ALP in biofluids. (C) 2021 Elsevier B.V. All rights reserved.
FA-MoOx QDsCu2+ ionAlkaline phosphataseBiofluids and fluorescence assayONE-POT SYNTHESISASCORBIC-ACIDCARBON DOTSASSAYSENSORPROBEPRECONCENTRATIONSTRATEGYSORBENTGROWTH
NSTL
Elsevier
