首页|Conjugate of meso-carboxysubstituted-BODIPY with thioterpenoid as an effective fluorescent probe: Synthesis, structure, spectral characteristics, and molecular docking

Conjugate of meso-carboxysubstituted-BODIPY with thioterpenoid as an effective fluorescent probe: Synthesis, structure, spectral characteristics, and molecular docking

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  • NSTL
  • Elsevier
This paper is devoted to the design of a fluorescent probe based on meso-carboxysubstituted-BODIPY with a thioterpene fragment. The functional replacement of the methoxy group in the BODIPY molecule on a thioterpene fragment was carried out in order to find out the antiplatelet and anticoagulant action mechanisms of thioterpenoids and to assess the membrane and receptor factors contributions. The molecular structure of the conjugate was confirmed via UV/vis-, NMR- and MS-spectra. It is found that the probe is a high fluorescence quantum yield (to similar to 100%) in the blue-green region at 509-516 nm. Molecular docking of all studied molecules showed that the BODIPY with terpenoid conjugation is an excellent way to increase their affinity to platelet receptor PY12. (C) 2021 Elsevier B.V. All rights reserved.

BODIPYThioterpenoidConjugateStructureSpectral propertiesMolecular dockingANTIFUNGAL ACTIVITYBASIS-SETSDERIVATIVESMONOTERPENOIDSDESIGNDYES

Guseva, Galina B.、Antina, Elena, V、Berezin, Mikhail B.、Ksenofontov, Alexander A.、Bocharov, Pavel S.、Smirnova, Anastassia S.、Pavelyev, Roman S.、Gilfanov, Ilmir R.、Pestova, Svetlana, V、Rubtsova, Svetlana A.、Kayumov, Airat R.、Kiselev, Sergei, V、Azizova, Zulfiya R.、Ostolopovskaya, Olga, V、Efimov, Sergey, V、Klochkov, Vladimir V.、Khodov, Ilya A.、Nikitina, Liliya E.、Izmest'ev, Evgeny S.

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Russian Acad Sci

Kazan Fed Univ

Kazan State Med Univ

2022

10.1016/j.saa.2021.120638

Spectrochimica acta

Spectrochimica acta

ISSN：1386-1425
年,卷(期)：2022.268
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