首页|Mechanical characteristics of BMSCs-intervened sciatic nerve in chronic alcohol-intoxicated animal model
Mechanical characteristics of BMSCs-intervened sciatic nerve in chronic alcohol-intoxicated animal model
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Taylor & Francis
ABSTRACT Objective: To study the mechanical properties of sciatic nerve in rats with chronic alcoholism (CA) and intervened with bone marrow mesenchymal stem cells (BMSCs) and to provide bio-mechanical basis for clinical practice. Methods: the serum of the BMSCs-intervened CA rats was sampled and determined the contents of malondialdehyde (MDA), metallothionein (CAS, MT), and Glutathione/r -glutamyl cys-teinyl/glycine (GSH); meanwhile, the rats' sciatic nerve was tested the tensile and observed the histomorphological changes. Results: The mechanical properties of sciatic nerve in BMSCs-intervened CA rats, as well as the serum levels of MT and GSH, were significantly different from those in the basic fibroblast growth factor (bFGF)-intervened CA rats (p<0.05). Conclusions: BMSCs intervention can restore the levels of MT, GSH, MDA, histomorphology, and tensile mechanical properties in CA animal model, and its effects on repairing sciatic nerve are obvious.
Animal model of alcoholismsciatic nerve injurybone marrow mesenchymal stem cell interventionbasic fibroblast growth factor interventionmechanical property
Peng Li、Yudong Chen、Kun Yang、Dachuan Chen、Daliang Kong
展开 >
Department of Mechanics, School of Mechanical and Aerospace Engineering, Jilin University
NSTL
Taylor & Francis
