首页|Decreased risk of COVID-19 pneumonia in children and adolescents during the Delta variant emergence
Decreased risk of COVID-19 pneumonia in children and adolescents during the Delta variant emergence
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NSTL
Elsevier
Objectives: This study aimed to evaluate factors associated with the risk of COVID-19 pneumonia in children (aged <10 years) and adolescents (aged 10-19 years) before (March 2020-April 2021) and during (May-July 2021) the Delta (B.1.617.2) variant emergence. Study design: A retrospective and nationwide cohort study was conducted in Mexico. Methods: Data from 26,961 laboratory-confirmed cases of COVID-19 were analyzed. Risk ratios (RRs) and 95% confidence intervals (CIs) were used to evaluate the association of the evaluated exposures with the risk of COVID-19 pneumonia. Results: The overall incidence rate of pneumonia was 23.0 per 10,000 person-days, and it was lower during the Delta variant emergence (30.3 vs. 9.4 person-days, p < 0.001). In multiple analysis, a decreased risk of pneumonia was observed among those cases occurring in May 2021 or later (vs. March 2020-April 2021, RR = 0.98, 95% CI 0.97-0.99) and among older patients (RRper year = 0.998, 95% CI 0.996 -0.998). Other comorbidities (namely, obesity, chronic kidney disease, diabetes mellitus, immunosuppression, or malignant tumors) were associated with an increased risk of severe COVID-19 manifestations. Conclusions: Our findings suggest that during the Delta variant emergence, children and adolescent patients were at reduced risk of COVID-19 pneumonia in Mexico. Further research is needed to identify factors determining the observed scenario. (c) 2021 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
ChildAdolescentCOVID-19SARS-CoV-2Pneumonia
Murillo-Zamora, E.、Trujillo, X.、Huerta, M.、Rios-Silva, M.、Baltazar-Rodriguez, L. M.、Guzman-Esquivel, J.、Benites-Godinez, V.、Ortega-Ramirez, A. D.、Mendoza-Cano, O.
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Dept Epidemiol,Inst Mexicano Seguro Social
Ctr Univ Invest Biomed,Univ Colima
Ctr Univ Invest Biomed,Univ Colima CONACyT
Fac Med,Univ Colima
Coordinac Educaci Salud,Inst Mexicano Seguro Social
NSTL
Elsevier
