首页|Histone gene editing probes functions of H3K27 modifications in mammals
Histone gene editing probes functions of H3K27 modifications in mammals
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NSTL
A new study employs CRISPR-Cas9-based base editing for simultaneous mutagenesis of all copies of histone H3 genes in mammals， highlighting the functional importance of H3K27me3 for Polycomb-mediated gene silencing and the dispensability of H3K27ac in transcriptional activation。
NSTL
