首页|Analytical tools for antibody–drug conjugates: From in vitro to in vivo

Analytical tools for antibody–drug conjugates: From in vitro to in vivo

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© 2022 Elsevier B.V.Over the last decade, the biopharmaceutical market has witnessed a new wave of development in antibody–drug conjugates (ADCs) due to their high efficacy in cancer treatment. To date, thirteen U.S. Food and Drug Administration approved ADCs are available for clinical use. ADC development is dependent on analytical tools for comprehensively characterizing ADCs, from their biochemical attributes (such as drug-to-antibody ratio and conjugation sites) to their in vivo dynamics. This review will provide a general overview of ADC characterization from in vitro tests to in vivo dynamics. Recent advances in analytical techniques are helping us to better understand and optimize the quality, safety, and efficacy of ADCs. The advantages and limitations of these approaches will be described, and the challenges and potential opportunities for future ADC characterization will be discussed. The review will provide insights for the development of ADC analytical approaches, in turn facilitating the development of ADC drugs.

Antibody–drug conjugatesBioimagingIn vivo analysisLiving cellsNIR fluorescence

Deng R.、Liu T.、Tao Y.、Zhang Y.、Wang Y.、Xia X.

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College of Biomass Science and Engineering Sichuan University

Targeted Tracer Research and Development Laboratory Institute of Respiratory Health Frontiers Science Center for Disease-related Molecular Network National Clinical Research Center for Geriatrics West China Hospital Sichuan University

2022

10.1016/j.trac.2022.116621

TrAC

TrAC

ISSN：0165-9936
年,卷(期)：2022.152
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