首页|High pressure Raman investigation on trans-urocanic acid

High pressure Raman investigation on trans-urocanic acid

扫码查看
原文链接
  • NSTL
  • Elsevier
Trans-urocanic acid (t-UCA) is an important epidermal UV protector predominantly found in human skin. Exposure of UV radiation triggers photoisomerization of t-UCA into its other conformer, cis-urocanic acid (cis-UCA), which has been shown to be a mediator of UV-induced immune-suppression leading to skin cancer. In this report, we present the investigation of molecular changes of t-UCA under high pressures by in-situ high pressure Raman spectroscopy. The study indicates onset of ring opening polymerization of t-UCA at pressure above 1.4 GPa. At pressures beyond 5 GPa, a well discernible characteristic vibrational mode (C=C stretch) accompanied by several other spectral features such as delta CO2- and delta N-H modes of cis-UCA point towards the isomerization of residual t-UCA monomers into cis-UCA. The content of cisUCA gradually increased with increase in pressure. On release to ambient conditions, the spectrum of the quenched sample showed Raman modes of polymer and cis-UCA indicating that the changes are irreversible. (C) 2021 Elsevier B.V. All rights reserved.

Trans-urocanic acidHigh pressureRamanCis-urocanic acidIsomerizationPolymerizationSOLID-STATE POLYMERIZATIONRH COMPLEX CATALYSTINDUCED CISAROMATIC POLYACETYLENESIMMUNE SUPPRESSIONISOMERIZATIONPHOTOISOMERIZATIONSPECTROSCOPYAZOBENZENESCATTERING

Kumar, Naveen、Murli, C.、Varma, Meera、Poswal, H. K.、Thomas, S.、Kshirsagar, R. J.

展开 >

Bhabha Atom Res Ctr

2022

10.1016/j.saa.2021.120438

Spectrochimica acta

Spectrochimica acta

ISSN：1386-1425
年,卷(期)：2022.266
  • 1
  • 71