首页|Specificity of the peroxisome proliferation response in mussels exposed to environmental pollutants

Specificity of the peroxisome proliferation response in mussels exposed to environmental pollutants

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Peroxisome proliferation has been proposed as novel biomarker of exposure to organic pollutants in aquatic organisms. Peroxisome proliferator compounds comprise a heterogeneous group of substances known for their ability to cause massive proliferation of peroxisomes and liver carcinogenesis in sensitive species such as rodents. Recently, several marine organisms (mussels and fish) have been shown as target species of peroxisome proliferators. In the present work, we aimed to investigate the specificity of the peroxisome proliferation response in mussels. For this purpose, mussels (Mytilus edulis) were exposed for three weeks to North Sea crude oil (NSO), a mixture of NSO, alkylphenols and extra PAHs (MIX), diallylphthalate (DAP), bisphenol-A (BPA) and tetrabromodiphenylether (TBDE), or transplanted for three weeks to four stations showing different copper concentrations in a copper mine. Peroxisome proliferation was assessed by measuring the activity of the peroxisomal beta -oxidation enzyme acyl-CoA oxidase (AOX) and the volume density occupied by peroxisomes (V sub(V) sub(P)) in the digestive gland. Mussels exposed to NSO and MIX showed significantly increased AOX activities and V sub(V) sub(P) compared to control animals. Significantly higher V sub(V) sub(P) was also found in DAP and TBDE exposed mussels. V sub(V) sub(P) did not vary in mussels transplanted into a copper concentration gradient. Our results confirm the usefulness and specificity of peroxisome proliferation as a suitable biomarker of exposure to organic contaminants such as oil derived hydrocarbons, phthalate plasticizers and polybrominated flame retardants in mussels.

Acyl-CoA oxidaseAquatic organismsAcyl-CoA oxidaseAquatic organismsBioindicatorsBiomarkersCarcinogenesisContaminantsCopperCrude oilDensityDigestive glandsEnzymesExposureFire retardant chemicalsFire retardantsFishGlandsHydrocarbonsLiverMarine molluscsMarine organismsMinesMusselsMytilusOilOrganic CompoundsPeroxisomesPlasticizersPollutantsPollution effectsPollution indicatorsRetardantsRodentsSpecificityToxicity testsalkylphenolsbiomarkersphthalatesMytilus edulisANENorth SeaNorth Sea

Cajaraville MP、Ortiz-Zarragoitia M

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Zoologia eta Biologia Zelularra Saila, Zientzia eta Teknologia Zoologia eta Biologia Zelularra Saila, Zientzia eta Teknologia Fakultatea, Euskal Herriko Unibertsitatea, UPV/EHU, 644 P.K., E-48080 Bilbao, Basque Country, Spain, [mailto:mirenp.cajaravi

2006

Aquatic Toxicology

Aquatic Toxicology

SCI
ISSN：0166-445X
年,卷(期)：2006.78(Suppl.)