首页|Regioselective Hydrothiolation of Allenoates through a Ca(OTf)2-Promoted Three-Component Reaction

Regioselective Hydrothiolation of Allenoates through a Ca(OTf)2-Promoted Three-Component Reaction

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An approach to synthesize α-substituted alkene derivatives via calcium-promoted hydrothiolation of allenoates is described.Employing diverse allenoates,and amines,a library of α-substituted alkenes is obtained with great regioselectivity and good to high yields.The reaction proceeds through the nucleophilic addition of in-situ generated dithiocarbamates to allenoates in a rapid mild method using an eco-friendly metal promoter.

allenoatesdithiocarbamatehydrothiolationregioselective reactionthree-component reaction

Aida Abdi、S.Sina Hosseini、Ali Nikbakht

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Peptide Chemistry Research Institute,K.N.Toosi University of Technology P.O.Box 15875-4416,Tehran,Iran

2022

doi.org/10.1002/slct.202203372

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Chemistry Select

ISSN：
年,卷(期)：2022.7(46)