首页期刊导航|Chemistry Select
期刊信息/Journal information
Chemistry Select
John Wiley & Sons, Inc.
Chemistry Select

John Wiley & Sons, Inc.

Chemistry Select/Journal Chemistry Select
正式出版
收录年代

    Selenium Dioxide as a Source to make Se-Containing Imidazoheterocycle or Aniline Derivatives

    Zijian ZhongJinfeng MaPan Xu
    5页
    查看更多>>摘要：Selenium dioxide is traditionally regarded as an oxidant and rather as a selenium source for making organseliums.Herein,we developed a new selenation method by using selenium dioxide instead of commonly used selenium powder or diselenides to generate Se-substituted imidazoheterocycle and aniline compounds.Furthermore,sodium arenesulfinates were selected as coupling partners instead of traditional aromatic halides.All reactions give desired products in moderate to excellent yields under mild conditions.
      原文链接:
    • NSTL

    A Series of Adenosine Analogs as the First Efficacious Anti-SARS-CoV-2 Drugs against the B.1.1.529.4 Lineage:A Preclinical Repurposing Research Study

    Amgad M.RabieMohnad Abdalla
    17页
    查看更多>>摘要：Given the rapid progression of the coronavirus disease 2019(COVID-19)pandemic,an ultrafast response was urgently required to handle this major public crisis.To contain the pandemic,investments are required to develop diagnostic tests,prophylactic vaccines,and novel therapies.Lately,nucleoside analog(NA)antivirals topped the scene as top options for the treatment of COVID-19 caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections.Meanwhile,the continuous generation of new lineages of the SARS-CoV-2 Omicron variant caused a new challenge in the persistent COVID-19 battle.Hitting the two crucial SARS-CoV-2 enzymes RNA-dependent RNA polymerase(RdRp)and 3’-to-5'exoribonuclease(ExoN)collectively together using only one single ligand is a very successful new approach to stop SARS-CoV-2 multiplication and combat COVID-19 irrespective of the SARS-CoV-2 variant type because RdRps and ExoNs are broadly conserved among all SARS-CoV-2 strains.Herein,the current comprehensive study investigated most NAs libraries,searching for the most ideal drug candidates expectedly able to perfectly act through this double tactic.Gradual computational filtration gave rise to six different promising NAs,which are riboprine,forodesine,tecadenoson,nelarabine,vidarabine,and maribavir,respectively.Further biological assessment proved for the first time,using the in vitro anti-RdRp/ExoN and anti-SARS-CoV-2 bioassays,that riboprine and forodesine,among all the six tested NAs,are able to powerfully inhibit the replication of the new virulent strains of SARS-CoV-2 with extremely minute in vitro anti-RdRp and anti-SARS-CoV-2 EC50 values of about 0.22 and 0.49 μM for riboprine and about 0.25 and 0.73 μM for forodesine,respectively,surpassing both remdesivir and the new anti-COVID-19 drug molnupiravir.The prior in silico data supported these biochemical findings,suggesting that riboprine and forodesine molecules strongly hit the key catalytic pockets of the SARS-CoV-2(Omicron variant)RdRp’s and ExoN’s main active sites.Additionally,the ideal pharmacophoric features of riboprine and forodesine molecules render them typical dual-action inhibitors of SARS-CoV-2 replication and proofreading,with their relatively flexible structures open for diverse types of chemical derivatization.In Brief,the current important results of this comprehensive study revealed the interesting repurposing potentials of,mainly,the two nucleosides riboprine and forodesine to effectively shut down the polymerase/exoribonuclease-RNA nucleotides interactions of the SARS-CoV-2 Omicron variant and consequently treat COVID-19 infections,motivating us to rapidly begin the two drugs'broad preclinical/clinical anti-COVID-19 bioevaluations,hoping to combine both drugs soon in the COVID-19 treatment protocols.
      原文链接:
    • NSTL

    Photocatalytic Degradation of Bisphenol A by TiO2 Mineralized Using a Polystyrene-Peptide Template

    Yue XuYujie WuSeung Hyun Hur
    7页
    查看更多>>摘要：Biomineralization is an environment-friendly strategy for producing inorganic materials,where nitrogen-doped particles of controlled size can be synthesized.A peptide-mediated biomineralization was investigated to produce TiO2 particles with enhanced photocatalytic activity.The heptapeptide,HKKPSKS,verified previously as exhibiting TiO2 mineralizing activity,was immobilized on the surface of functionalized polystyrene(PS)bead through N-ethyl-N-(3-dimethylamino-propyl)carbodii-mide hydrochloride-N-hydroxy-succinimide(EDCNHS)coupling,so that it acted as the nucleus to trigger TiO2 precipitation on its surface in ambient condition.During the calcination of PS peptideTiO2,the PSpeptide template both allowed the formation of porous-structured particles,and generated nitrogen-doped crystalline mixed phase(anatase/rutile)TiO2.More than 86% of bisphenol A(BPA)was decomposed in the presence of optimally calcined TiO2 under visible light in 2 h,whereas commercial P25 catalyst degraded 48% of BPA.After five cycles of repeated reactions for BPA degradation,the photocatalytic activity of TiO2 decreased by less than 10%.
      原文链接:
    • NSTL

    Visible-Light Enabled Late-Stage,Room-Temperature Aminocarbonylation of Aryl Iodides with Labeled Carbon Monoxide

    Kim S.MuhlfenzlMalvika SardanaTroels Skrydstrup
    6页
    查看更多>>摘要：In recent years,coupling reactions mediated by visible light have been widely studied because such reactions can often be run at significantly lower temperatures.In this work,aryl iodides were coupled with amines at ambient temperature in the presence of stoichiometric amounts of carbon monoxide using visible-light irradiation and palladium catalysis.A wide range of aryl substrates,both electron-deficient and rich,as well as heterocycles,were carbonylated to provide the corresponding amides in moderate to good yields based on CO.In addition,the generality of the amine was investigated,and primary and secondary amines yielded the desired products in moderate to good yields.This methodology was also successfully applied to the synthesis of pharmaceuticals and the incorporation of a carbon-14 label into the carbonyl group,where the use of 9-methyl-fluorene-9-carbonyl chloride(COgen)as the carbon isotope-labeled CO source allowed easy translation between the unlabeled and the labeled transformations.
      原文链接:
    • NSTL

    DABCOnium Ionic Liquid-Immobilized Silica Gel for Solid Phase Extraction of Phenoxyacetic Acid Herbicides in Water Samples**

    The Thai NguyenThinh Phuc NguyenLong Nam Tran
    7页
    查看更多>>摘要：A novel sorbent(SiO2-(CH2)3-DABCO)for solid-phase extraction(SPE)was successfully prepared by chemical-bonding formation of diazabicyclo[2.2.2]octane ionic liquid onto silica gel.The structure of SiO2-(CH2)3-DABCO sorbent was characterized by FT-IR,TGA,SEM,EDX,and BET methods.Cartridges packed with the synthetic SiO2-(CH2)3-DABCO were used for the preconcen-tration of trace-level of phenoxyacetic acid herbicides in water samples for the first time.The factors influencing on the recovery were investigated,such as type of ion liquids,loading volume,eluents,elution volume,loading rate,and capacity.After the enrichment,the phenoxyacetic acid herbicides were analyzed by high-performance liquid chromatography with an ultraviolet detector.Four model phenoxyacetic acid herbicides,including 2-methyl-4-chlorophenoxyacetic acid(MCPA),2,4,5-trichlorophenoxyacetic acid(2,4,5-T),fenoprop(2,4,5-TP)and haloxyfop were well retained and separated by this material with a recovery efficiency from 77 to 103%.The SiO2-(CH2)3-DABCO demonstrated a good capacity corresponding to 0.56 mg of the analyte adsorbed per 100 mg of the material.The mixture of phosphate buffer(pH 7):MeOH(50:50,v/v)was used to elute the analytes and provided the highest recovery with the standard deviations from 2.4 to 6.5.The high sensitivity with detection limits of 1.070-9.587 μg/L can be achieved.
      原文链接:
    • NSTL

    Ability of Shirasu-based Material for Adsorption of Metal Ions and Its Promotion for Catalytic Decomposition of Nitrous Oxide

    Tetsuo UmegakiDaisuke NoguchiTsubasa Fukumoto
    5页
    查看更多>>摘要：This work investigated ability of Shirasu-based material for adsorption of metal ions and their promotion effect for catalytic decomposition of nitrous oxide.Catalytically active cobalt and copper species were adsorbed on the Shirasu-based material by immerse process of aqueous matal solutions.In all the Co/Cu ratios(Co/(Co+Cu)= 1,0.75,and 0.5),cobalt species were preferentially adsorbed on the Shirasu-based material.The cobalt species tended to be adsorbed on the silica sites of the sample with Co/(Co+Cu)= 0.75.and the catalyst exhibited the highest activity for decomposition of nitrous oxide.Introduced nitrous oxide was completely decomposed at the reaction temperatures above 673 K.
      原文链接:
    • NSTL

    Removal of Toxic Dyes and Paraquat by a Dual-Functional Metal-Organic Framework

    Hai-Yan SunYu-Jie GaoJi-Long Li
    7页
    查看更多>>摘要：Environmental contamination due to organic pollutants including organic dyes(e.g.,methylene blue(MB))and paraquat(i.e.,methyl viologen(MV))has become a serious problem.Herein,the removal for toxic cations of methylene blue(MB+)and methyl viologen(MV~(2+))has been realized by a three-dimensional(3D)anionic microporous metal-organic framework,namely[Me2NH2][In(TDC)2]·1.5DMA·H2O(FJSM-InMOF).FJSM-InMOF is capable of selectively adsorbing MB+in the presence of various dyes due to the effects of size-exclusion and charge-matching.Particularly,the strategy of combining adsorption and photocatalytic degradation realizes the thorough treatment of MB+,which has been rarely reported.The adsorbent material can be easily regenerated and reused.Moreover,FJSM-InMOF exhibits a high capacity and rapid kinetics towards more toxic MV2+.This work poses a new way for the selective removal of cationic organic pollutants and highlights the significance of combining different methods for the decontamination of organic pollutants.
      原文链接:
    • NSTL

    Purification and Characterization of Lipoxygenase from Walnuts(Juglans Regia)and Investigation of the Effects of Some Phenolic Compounds on the Activity

    Arzu Ozturk Kesebir
    8页
    查看更多>>摘要：This study reports the purification and characterization of lipoxygenase protein from walnut(Juglans regia).Lipoxygenases(LOX)are the key enzyme of germination in plants.Purification of LOX was 62,28 fold in 68% yield with a specific activity of 24.29 U/mg using ammonium sulfate precipitation and DEAE-Sepharose Fast Flow Ion Exchange Column.The optimum pH value of the enzyme was determined as pH 7 and the optimum temperature value as 30℃.It was determined that morin hydrate,p-coumaric acid,syringaldehyde and vanillic acid inhibited LOX,and their IC_(50)values were 304 μM,233 μM,643.2 μM and 218.1 μM respectively.It has been concluded that walnut,which is used frequently in many parts of the world,is a good source of LOX and this study can be a guide for studies in medicine,food industry,cosmetics and pharmacy.
      原文链接:
    • NSTL

    A Non-Enzymatic and Electrochemical-Based Sensor using a Prussian Blue-Gold Nanoparticle-Reduced Graphene Oxide Ternary Nanocomposite for Efficient Hydrogen Peroxide Detection.

    Seema ChauhanChhaya Sharma
    7页
    查看更多>>摘要：An electrochemical sensor has been developed using PBNCs/AuNPs/RGO ternary nanocomposite,in which gold nanopar-ticles(AuNPs)are deposited on Prussian blue nanocubes(PBNCs)and reduced graphene oxide(RGO)using two-step in-situ synthetic approach.The synthesized ternary nanocomposite shows high catalytic activity towards H2O2 sensing due to the synergistic effect of gold nanoparticles and RGO.The material was prepared by the co-precipitation method,and the morphology of the synthesized composites was characterized using X-Ray diffraction(XRD),scanning electron microscopy(SEM),and High-resolution Transmission electron microscopy(HR-TEM).Electrochemical measurements were performed by modifying glassy carbon electrodes(GCE)with bare PBNCs,PBNCs/RGO,and PBNCs/AuNPs/RGO for low-level detection of H2O2 using Cyclic Voltammetry(CV)and Chronoamperometry.The interference property was analyzed using ascorbic acid(AA),uric acid(UA),and glucose as interfering agents.The modified electrode shows high sensitivity of 5.47 nA/nM and a limit of detection of 260 pM for H2O2 at(S/N = 3).This electrochemical sensor observed a linear range of detection from 0.66 nM to 10.53 nM.The proposed sensor exhibits good stability,better selectivity,and a picomolar concentration detection limit for H2O2.
      原文链接:
    • NSTL

    Regioselective Hydrothiolation of Allenoates through a Ca(OTf)2-Promoted Three-Component Reaction

    Aida AbdiS.Sina HosseiniAli Nikbakht
    6页
    查看更多>>摘要：An approach to synthesize α-substituted alkene derivatives via calcium-promoted hydrothiolation of allenoates is described.Employing diverse allenoates,and amines,a library of α-substituted alkenes is obtained with great regioselectivity and good to high yields.The reaction proceeds through the nucleophilic addition of in-situ generated dithiocarbamates to allenoates in a rapid mild method using an eco-friendly metal promoter.
      原文链接:
    • NSTL