The characteristics of missed pharyngeal and laryngeal cancers at gastrointestinal endoscopy

Nakajo, Keiichiro ¹Inaba, Atsushi ¹Aoyama, Naoki ¹Takashima, Kenji ¹Kadota, Tomohiro ¹Yoda, Yusuke ¹Morishita, Youhei ²Okano, Wataru ¹Tomioka, Toshifumi ¹Shinozaki, Takeshi ¹Matsuura, Kazuto ¹Hayashi, Ryuichi ¹Akimoto, Tetsuo ³Yano, Tomonori¹

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作者信息

1. Dept Gastroenterol & Endoscopy,Natl Canc Ctr Hosp East
2. Dept Head & Neck Surg,Natl Canc Ctr Hosp East Hosp
3. Cooperat Grad Sch,Jikei Univ
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Abstract

Objectives: Understanding the miss rate and characteristics of missed pharyngeal and laryngeal cancers during upper gastrointestinal endoscopy may aid in reducing the endoscopic miss rate of this cancer type. However, little is known regarding the miss rate and characteristics of such cancers. Therefore, the aim of this study was to investigate the upper gastrointestinal endoscopic miss rate of oro-hypopharyngeal and laryngeal cancers, the characteristics of the missed cancers, and risk factors associated with the missed cancers. Methods: Patients who underwent upper gastrointestinal endoscopy and were pathologically diagnosed with oro-hypopharyngeal and laryngeal squamous cell carcinoma from January 2019 to November 2020 at our institution were retrospectively evaluated. Missed cancers were defined as those diagnosed within 15 months after a negative upper gastrointestinal endoscopy. Results: A total of 240 lesions were finally included. Eighty-five lesions were classified as missed cancers, and 155 lesions as non-missed cancers. The upper gastrointestinal endoscopic miss rate for oro-hypopharyngeal and laryngeal cancers was 35.4%. Multivariate analysis revealed that a tumor size of <13 mm (odds ratio: 1.96, P=0.026), tumors located on the anterior surface of the epiglottis/valleculae (odds ratio: 2.98, P=0.045) and inside of the pyriform sinus (odds ratio: 2.28, P=0.046) were associated with missed cancers. Conclusions: This study revealed a high miss rate of oro-hypopharyngeal and laryngeal cancers during endoscopic observations. High-quality upper gastrointestinal endoscopic observation and awareness of missed cancer may help reduce this rate.

Key words

pharyngeal neoplasms/oropharyngeal neoplasms/hypopharyngeal neoplasms/endoscopy/missed diagnosis/LONG-TERM

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出版年

2022

Japanese journal of clinical oncology.

ISSN：0368-2811

被引量2

参考文献量35

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