首页|In silico investigation of symptom development model based on coat protein interactions of two cucumber mosaic virus strains
In silico investigation of symptom development model based on coat protein interactions of two cucumber mosaic virus strains
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Elsevier
? 2022Cucumber mosaic virus (CMV) causes serious diseases in agricultural crops worldwide, predominantly in vegetable and ornamental plants. A critical interaction has been reported between the plant Ferredoxin I (Fd I) protein with the coat protein (CP) of the M strain of CMV (M-CMV) but not by the CP of the Q strain of CMV (Q-CMV). To ascertain the most likely symptom development model based on CMV CP interacting with the plant Fd I protein, further in silico investigation was performed on the CPs of the strains Q-CMV and M-CMV. The biological assembly of the CMV CP in virions is composed of hexameric and pentameric units. The results showed that there were significantly different interactions between pentameric and hexameric forms of M and Q-CMV CPs with Fd I. Pentameric structural forms of M-CMV CP interact strongly with Fd I compared to pentameric structures of Q-CMV CP, while there were no significant differences in the affinities of hexameric structures for Fd I between M and Q-CMV CPs. it can be deduced that probably pentameric structures of M-CMV CP block activation of plant Fd I protein. Therefore, it could be hypothesized that trapping Fd I in the complex of pentameric structures can lead to inhibition of the activity of plant Fd I in the photosynthetic electron transport chain leading the severe symptom development seen in M-CMV infected plants but not in Q-CMV infected plants. It seems likely that any factor that inhibits the interaction of CMV CPs with plant Fd I can prevent this symptom development.
Coat proteinCucumber mosaic virusFerredoxin I proteinPentameric structure
Akbarimotlagh M.、Shams-bakhsh M.、Arab S.S.、Palukaitis P.
展开 >
Plant Pathology Department Faculty of Agriculture Tarbiat Modares University
Department of Biophysics Faculty of Biological Sciences Tarbiat Modares University
Department of Horticultural Sciences Seoul Women's University
NSTL
Elsevier
