首页|New porphyrin photosensitizers-Synthesis, singlet oxygen yield, photophysical properties and application in PDT
New porphyrin photosensitizers-Synthesis, singlet oxygen yield, photophysical properties and application in PDT
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NSTL
Elsevier
This research on porphyrin-based photosensitizer system has a very important theoretical and practical significance in the photodynamic therapy (PDT) treatment of cancer. Based on this, in this article, a series of porphyrin derivatives were first designed and synthesized, and a "push-pull " porphyrin photosensitizer with two symmetrical ethanethioate groups was finally constructed. Based on the characterization of their chemical structures (H-1 and C-13 NMR, MS, IR, and UV-Vis spectroscopy) and the use of the density functional theory (DFT) and time dependent DFT (TDDFT) to address the nature of the excited states as well as the dark/phototoxicity, the results have indicated the relationship between the porphyrin structure and properties. The experimental and theoretical UV-Vis absorption properties of porphyrins were discussed. The four porphyrin compounds synthesized all demonstrated a high capacity to generate singlet oxygen under long-wavelength (590 nm) light and low dark toxicity. Compared with the conventional porphyrin photosensitizers, P4 with a CT band (from 580 to 750 nm) is beneficial to the penetration of the light, presenting the potential for applications in PDT.
NSTL
Elsevier
