首页|Nano-Selenium and Macleaya cordata Extracts Improved Immune Functions of Intrauterine Growth Retardation Piglets under Maternal Oxidation Stress
Nano-Selenium and Macleaya cordata Extracts Improved Immune Functions of Intrauterine Growth Retardation Piglets under Maternal Oxidation Stress
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NSTL
Springer Nature
Intrauterine growth retardation (IUGR) is the main death cause of newborn piglets in large-scale farms。 To investigate the effects of maternal nano-selenium (nano-Se) and Macleaya cordata extracts (MCE) on immune functions of IUGR piglets in large scale farms， a 2 x 2 factorial design was adopted in this test， and two factors were nano-Se (0， 0。50 mg/kg) and MCE (0， 500 mg/kg)。 A total of 32 ternary hybrid sows (Landrace x Yorkshire x Duroc， parity 2) were used in this 25-day trial from day 90 of pregnancy to delivery。 The dietary treatments were as follows: (1) CON group， basic diet (0。0 mg/kg Se); (2) Nano-Se group， basic diet + 0。50 mg/kg added Se (nano-Se); (3) MCE group， basic diet + 500 mg/kg added MCE; (4) Combined group， basic diet + 0。50 mg/kg added nano-Se and 500 mg/kg added MCE。 Maternal nano-Se or combination of nano-Se and MCE diets extremely increased the superoxide dismutase (SOD)， catalase (CAT)， superoxide dismutase (GSH-Px) contents in the serum and liver of IUGR offspring (P < 0。05)， and MCE supplementation in sow diets remarkably increased the serum superoxide dismutase (SOD)， catalase (CAT)， and superoxide dismutase (GSH-Px) contents of IUGR piglets (P < 0。05)。 Adding nano-Se， MCE， or nano-Se and MCE to sow diets decreased the malondialdehyde (MDA) content in the serum and liver of IUGR piglets (P < 0。05)。 The supplementation of nano-Se and combined diets extremely increased the activities of immunoglobulin G (IgG) and immunoglobulin A (IgA) in the serum and liver of IUGR offspring (P < 0。05)。 Maternal nano-Se， MCE， and combined diets greatly decreased the levels of tumor necrosis factor-alpha (TNF-alpha)， interleukin 6 (IL-6)， and interleukin-1 beta (IL-1 beta) in the serum and liver of IUGR piglets (P < 0。05)。 Together， the application of nano-Se and/or MCE to sow diets improved antioxidant capacities and immune functions of IUGR offspring， and alleviated oxidative stress。
NSTL
Springer Nature
