查看更多>>摘要：Although the pathogenesis of immune thrombocytopenia is not fully known， oxidative stress is one of the etiological causes。 Copper and zinc are elements in the antioxidant system， and their deficiency causes oxidative stress。 We aimed to determine the serum copper and zinc levels and their effects on the response to treatment in patients with immune thrombocytopenia。 We analyzed 51 patients with primary immune thrombocytopenia and 33 control cases。 Age， gender， and platelet values at the time of diagnosis， drugs used for the treatment of immune thrombocytopenia， remission status， and serum copper and zinc levels were recorded。 The primary immune thrombocytopenia and control groups were compared in terms of serum copper and zinc levels。 In addition， the relationship between the response status to the treatment of patients with immune thrombocytopenia and serum copper and zinc levels was investigated。 The serum zinc level in the immune thrombocytopenia group and control group was 10。35 +/- 3。28 mu mol/L and 12。82 +/- 2。41 mu mol/L， respectively (p = 0。01)。 The serum copper level in patients with immune thrombocytopenia (77。3 +/- 22。23 mu g/dL) was significantly lower than the control group (99。4 +/- 20。82 mu g/dL) (p = 0。01)。 A significant correlation was found between the response to first-line treatment of primary immune thrombocytopenia and serum copper level (p = 0。005)。 The serum copper level was significantly lower in relapsed cases (p = 0。001)。 In conclusion， serum copper and zinc levels are lower in patients with primary immune thrombocytopenia than in healthy cases。 Patients with relapsed or unresponsive to immune thrombocytopenia treatment have lower serum copper levels than other patients。
查看更多>>摘要：Atrial fibrillation (AF) is the most common sustained dysrhythmia in the elderly population。 It is estimated to affect more than 30 million people worldwide。 AF occurs when abnormal electrical impulses start to activate in the atria and override the heart's natural pacemaker， which can no longer control the heart's rhythm。 Since atrial contractility is impaired in AF， blood flow in the atria becomes stasis over time and causes thrombus formation。 This thrombus causes the risk of embolism and causes complications such as stroke。 Therefore， it is a fundamental cause of cardiovascular mortality and morbidity。 The diagnosis of AF is usually made with the help of electrocardiography (ECG)。 The absence of P waves in ECG and irregular R-R interval is sufficient for diagnosis。 AF is most commonly associated with advanced age， hypertension， diabetes mellitus， thyroid dysfunction， obesity， alcohol use， physical inactivity， and underlying ischemic heart diseases。 As well as to all these usual risk factors， electrolyte disorders and mineral deficiencies also play an essential role in the etiology of AF。 Previous studies have clearly demonstrated that serum electrolyte changes have a role in the etiology of AF。 These include electrolytes such as serum magnesium， calcium， potassium， and chloride。 However， there is not enough information in the literature about the effects of trace elements on AF。 Selenium is a trace element that plays an important role in many systems in the human body。 It has a vital role in inflammation， regulation of antioxidant reactions， and fibrosis of tissues in both animals and humans。 It is known that selenium deficiency causes many cardiovascular diseases such as heart failure， coronary artery disease， and arrhythmia。 Our study aimed to compare serum selenium levels in newly diagnosed AF patients with the healthy control group。
查看更多>>摘要：In this study， we investigated the associations between cadmium (Cd) and lead (Pb) co-exposure， and serum ion levels in two populations living near a mining/smelting area and a nature reserve (control area)， respectively。 A total of 445 participants were included in this study。 Their blood cadmium (BCd)， blood lead (BPb)， and serum ion levels were determined， and the association between exposure levels and serum ion levels was analyzed。 The exposure levels of subjects living in the polluted area were significantly higher (p < 0。001)。 Lower levels of potassium， inorganic phosphorus， and iron were observed in subjects from the polluted area， whereas their sodium and chloride levels were higher (p < 0。01)。 The anion gap in their serum was also significantly lower。 We observed positive dose-effect relationships between Cd and/or Pb exposure and serum sodium and chloride， and negative dose-effect relationships between Cd and/or Pb exposure and serum inorganic phosphorus， iron， as well as the anion gap。 High Cd-Pb， high Cd， and high Pb exposure led to modification effects in potassium， calcium， inorganic phosphorus， and iron levels， and the anion gap。 No synergistic effects were observed in our results。 In conclusion， our data demonstrate that Cd and Pb exposure， alone or in combination， can lead to serum ion imbalances。
查看更多>>摘要：Several studies have indicated that selenium deficiency may be detrimental in the context of various viral disorders， and in the case of COVID-19， several studies have reported heterogeneous results concerning the association of selenium deficiency with the severity of disease。 To summarize the available data surrounding the association of body selenium levels with the outcomes of COVID-19， a systematic search was performed in the Medline database (PubMed)， Scopus， Cochrane Library， Embase， and Web of Science using keywords including "SARS-CoV-2，" "COVID-19，" and "selenium，" Studies evaluating the association of COVID-19 with body selenium levels were included。 Among 1，862 articles viewed in the database search， 10 articles were included after title， abstract， and full-text review。 One study was further included after searching the literature again for any newly published articles。 Out of 11 included studies， 10 studies measured serum selenium level， and one study investigated urinary selenium level。 Three of 10 studies measured serum SELENOP level as well as selenium level。 Glutathione peroxidase-3 level in serum was also assessed in one study。 The reported outcomes were severity， mortality， and risk of COVID-19。 Nine studies indicated that a lower serum selenium level is associated with worse outcomes。 Two studies reported no significant association between serum selenium level and COVID-19。 In one study， urinary selenium level was reported to be higher in severe and fatal cases compared to non-severe and recovered patients， respectively。 In most cases， selenium deficiency was associated with worse outcomes， and selenium levels in COVID-19 patients were lower than in healthy individuals。 Thus， it could be concluded that cautious selenium supplementation in COVID-19 patients may be helpful to prevent disease progression。 However， randomized clinical trials are needed to confirm this。
查看更多>>摘要：We aimed to explore the relationship between intakes of food-derived antioxidants (zinc， vitamin E， beta-carotene， and selenium) and semen parameters in an infertile male population。 This is a cross-sectional study among infertile men (> 18 years) referred to Isfahan Fertility and Infertility Center in Iran from March 2019 to October 2019。 The main outcome measures were semen volume， sperm count， concentration， total motility， and morphology。 Micronutrients considered in this analysis were zinc， selenium， beta-carotene， and vitamin E。 A total of 350 infertile men with a mean (SE) age of 34。77 (0。42) were included in this study。 Selenium intake tended to be positively associated with higher semen volume (beta = 0。79; 95% CI: - 0。01， 1。59) and sperm total motility after adjustment for main confounders (beta = 2。64; 95% CI: - 3。61， 8。89)。 Intake of beta-carotene was only associated with higher sperm total motility (beta = 5。46; 95% CI: - 0。84， 11。77)。 No significant association was detected between intakes of zinc and vitamin E and semen parameters。 In a population of infertile adult men， selenium intake was associated with higher sperm total motility and semen volume， and in the case of beta-carotene， better sperm total motility。 Further， prospective studies are warranted。
查看更多>>摘要：Preeclampsia (PE) is a pregnancy-specific disorder， which is one of the leading causes of maternal， fetal， and neonatal death， particularly in developing countries。 Arsenic (As)， which is commonly found in soil and groundwater， has been associated with various complications of pregnancy， such as spontaneous abortion， hypertension， and stillbirth。 Hence， the study was used to explore the relationship between PE and blood concentration of As in this study。 Blood concentration of As during pregnancy was measured by inductively coupled plasma mass spectrometry (ICP-MS)。 The results shown that the mean blood concentration of As was gradually increased from the control group to the severe PE group (P < 0。0001)。 Elevated blood concentration of As was associated with the prevalence of PE (OR = 12。81， 95% CI: 2。43-67。39 and 27。55， 1。75-433。43 for middle and high vs。 low)。 Furthermore， elevated blood concentration of As was associated with the severity of PE。 Additionally， we observed that blood concentration of As was associated with the hypoproteinemia (P = 0。001， r(s) = 0。37)。 Blood concentration of As was negatively corelated with the mean corpuscular volume (MCV) (P = 0。040， r(s) = - 0。23) and positively corelated with the mean corpuscular hemoglobin concentration (MCHC) (P = 0。044， r(s) = 0。23)。 Overall， our results indicated that the blood concentration of As can significantly predict the occurrence of PE。 Additionally， we provided evidence that blood concentration of As may affect the occurrence of hypoproteinemia。 These findings may provide some ideas for the prevention of PE and pregnancy complications。
查看更多>>摘要：Intrauterine growth retardation (IUGR) is the main death cause of newborn piglets in large-scale farms。 To investigate the effects of maternal nano-selenium (nano-Se) and Macleaya cordata extracts (MCE) on immune functions of IUGR piglets in large scale farms， a 2 x 2 factorial design was adopted in this test， and two factors were nano-Se (0， 0。50 mg/kg) and MCE (0， 500 mg/kg)。 A total of 32 ternary hybrid sows (Landrace x Yorkshire x Duroc， parity 2) were used in this 25-day trial from day 90 of pregnancy to delivery。 The dietary treatments were as follows: (1) CON group， basic diet (0。0 mg/kg Se); (2) Nano-Se group， basic diet + 0。50 mg/kg added Se (nano-Se); (3) MCE group， basic diet + 500 mg/kg added MCE; (4) Combined group， basic diet + 0。50 mg/kg added nano-Se and 500 mg/kg added MCE。 Maternal nano-Se or combination of nano-Se and MCE diets extremely increased the superoxide dismutase (SOD)， catalase (CAT)， superoxide dismutase (GSH-Px) contents in the serum and liver of IUGR offspring (P < 0。05)， and MCE supplementation in sow diets remarkably increased the serum superoxide dismutase (SOD)， catalase (CAT)， and superoxide dismutase (GSH-Px) contents of IUGR piglets (P < 0。05)。 Adding nano-Se， MCE， or nano-Se and MCE to sow diets decreased the malondialdehyde (MDA) content in the serum and liver of IUGR piglets (P < 0。05)。 The supplementation of nano-Se and combined diets extremely increased the activities of immunoglobulin G (IgG) and immunoglobulin A (IgA) in the serum and liver of IUGR offspring (P < 0。05)。 Maternal nano-Se， MCE， and combined diets greatly decreased the levels of tumor necrosis factor-alpha (TNF-alpha)， interleukin 6 (IL-6)， and interleukin-1 beta (IL-1 beta) in the serum and liver of IUGR piglets (P < 0。05)。 Together， the application of nano-Se and/or MCE to sow diets improved antioxidant capacities and immune functions of IUGR offspring， and alleviated oxidative stress。
Rabelo Buzalaf, Marilia AfonsoCorrea de Oliveira, Edivaldo HerculanoCrespo-Lopez, Maria ElenaLima, Rafael Rodrigues...
13页
查看更多>>摘要：Mercury (Hg) is a toxic metal that became a public health problem due to environmental contamination caused by anthropogenic activity。 In this sense， oral homeostasis can undergo changes due to the toxic effects of metal on the salivary glands。 Therefore， our objective was to investigate the proteomic and genotoxic changes in salivary glands after exposure to inorganic mercury (IHg)。 Forty Wistar rats that were divided into a control group， which received distilled water， and an exposed group， which received 0。375 mg/kg of mercury chloride for 45 days via orogastric gavage。 After that， the animals were euthanized， and the parotid and submandibular glands were collected for analysis of the genotoxic effects， using the comet assay and proteome global profile assessment。 The results showed that IHg promoted damage to cellular DNA associated with proteomic changes that showed events such as oxidative stress， mitochondrial dysfunction， changes in the cytoskeleton， and apoptosis。 Therefore， these findings show a profile of molecular changes due to the interactions of IHg with several proteins and mechanisms inherent to the cell， which consequently may result in dysfunction of the salivary glands and impaired homeostasis of the oral cavity。
查看更多>>摘要：Obesity is a mild chronic inflammation that causes many metabolic diseases。 It was aimed to investigate some parameters affective on the energy metabolism by adding zinc (Zn， ZnSO4) to drinking water of diet-induced obese rats。 Five-week aged， male Sprague Dawley rats divided into as control group， consuming standard rat diet， and high-fat diet (HFD) group。 After obesity induced by feeding HFD for 8 weeks， the obese rats were divided into Zn-supplemented obese group (HFD + obese + Zn; 150 mg Zn/L (for 6 weeks)， 235 mg Zn/L (7th week)， 250 mg Zn/L (8th week) in drinking water) and obese group (HFD + obese)。 Mean body weight， serum concentrations of C-reactive protein， neuropeptide-Y， leptin， insulin fasting blood glucose， and HOMA-IR were statistically decreased by given Zn in HFD + obese + Zn group compared to HFD + obese rats。 It was observed that the total cholesterol， LDL， and HDL cholesterol levels of HFD + obese + Zn group became closer to the control group level， and Zn supplementation caused a statistically significant decrease in cholesterol profile than HFD + obese rats。 Also， increased mean serum nesfatin-1 level， an effective protein for the formation of satiety， was analyzed in HFD + obese + Zn group when compared to HFD + obese ones。 Serum triglyceride concentration tended to decrease with the effect of Zn in obese rats。 In conclusion， it can be said that oral use of Zn could improve energy balance and prevent the occurrence of metabolic diseases related to obesity depending on the anti-inflammatory effect of Zn。
NSTL
Springer Nature