首页|Genome-wide associations and metabolic disease: the big revolution.
Genome-wide associations and metabolic disease: the big revolution.
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NSTL
Since the birth of molecular genetics in the 1950s， researchers have been trying to unravel the genetic architecture of common metabolic disorders， with the hope that such insights could help develop new diagnostic and therapeutic tools。 Until recently， their efforts were based on two main approaches。 One involved the study of candidate genes with known metabolic functions。 The other considered genes located within chromosomal regions linked with metabolic alterations by studies of disproportionately affected families。 Then， early in 2007， the metabolic research field dramatically changed。 The first studies of genome-wide associations (GWA) were published that extended the search for genes involved in etiology of complex disorders to the entire genome。 These early publications were quickly followed by a deluge of studies describing application of the GWA approach to a variety of common disorders， including type 2 diabetes， obesity， hypertension， and dyslipidemias。
Genome基因组
Doria A、Abumrad NA
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2008
Current opinion in clinical nutrition and metabolic care
NSTL
