首页|BODIPY-based rapid response fluorescence probe for sensing and bioimaging endogenous superoxide anion in living cells
BODIPY-based rapid response fluorescence probe for sensing and bioimaging endogenous superoxide anion in living cells
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NSTL
Elsevier
The superoxide anion radical (O-2(center dot)), a pernicious ROS in living cells, has long been recognized as an important cell signaling molecule involved in numerous physiological and pathological processes, including innate immunity and metabolic homeostasis. Here, we developed a new bodipy-based fluorescent probe for monitoring O-2(center dot) based on the selective cleavage of phosphate bond in BODIPY-T by O-2(center dot) , producing a high-brightness fluorescent BODIPY-COOH. The probe exhibits excellent selectivity for O-2(center dot) with little interference from other ROS species. Fluorescence imaging of RAW264.7 cells also demonstrated successful detection of endogenous O-2(center dot) changes in living cells, indicating that BODIPY-T is a potential probe for the diagnosis and study of the corresponding diseases. (C) 2021 Elsevier B.V. All rights reserved.
NSTL
Elsevier
