首页|A ratiometric ESIPT fluorescent probe for detection of anticancer-associated H2O2 level in vitro and in vivo
A ratiometric ESIPT fluorescent probe for detection of anticancer-associated H2O2 level in vitro and in vivo
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NSTL
Elsevier
ROS is a significant factor in the cancer treatment mechanism. The monitoring anticancer-associated H2O2 level plays a vital role in the anticancer mechanistic exploration in pathology and physiology. Herein we synthesized a ratiometric fluorescent probe (HBQ-L) to detect and image H2O2 based on excited-state intramolecular proton transfer. HBQ-L had a high sensitivity (231-fold) with a low detection limit (28.5 nM) for monitoring H2O2 in solution. HBQ-L showed good mitochondrial-targeting and successfully detected both exo-/endogenous H2O2 in A549 cells. Furthermore, HBQ-L was used to ratio metric monitor H2O2 level in anticancer reagent DOX-treated cells or zebrafish. Importantly, it was employed to access the monitoring H2O2 in the A549 tumor-bearing mice. (C) 2022 Elsevier B.V. All rights reserved.& nbsp;
Ratiometric fluorescenceIn vivo imagingMitochondrial probeH-2 O-2 detectionIMAGING HYDROGEN-PEROXIDEINDUCED OXIDATIVE STRESSEXCITED-STATECANCER-CELLSGLUTATHIONECYSTEINEACTIVATIONEMISSIONSENSOR
NSTL
Elsevier
