首页|Peripheral blood flow regulation in response to sympathetic stimulation in individuals with down syndrome
Peripheral blood flow regulation in response to sympathetic stimulation in individuals with down syndrome
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
Individuals with Down syndrome (DS) experience autonomic dysfunction, with reduced sympathetic and parasympathetic control. This results in alterations in resting heart rate and blood pressure and attenuated responses to sympathoexcitatory stimuli. It is unknown to what extent this impacts the regulation of peripheral blood flow in response to sympathetic stimuli, which is an important prerequisite to exercise and perform work. Therefore, we aimed to investigate differences in peripheral blood flow regulation in response to lower body negative pressure (LBNP) between individuals with and without DS Methods: Participants (n = 10 males with DS and n = 11 male controls, mean age 23.7 years ± 3.2) underwent 5 min of LBNP stimulations (-20 mmHg), after resting supine for 10 min. One minute steady state blood pressure and blood flow at baseline and during LBNP were obtained for analysis. Mean flow velocity and arterial diameters were recorded with ul-trasonography; foreram blood flow (FBF), shear rate and forearm vascular conductance (FVC) were calculated using brachial blood pressure measured right before ultrasound recordings Results: Participants with DS responded differently (consistent with reduced vasoconstrictive control) to the LBNP stimulus (significant ConditionxGroup interaction effect) for mean velocity (p = 0.02), FBF (p = 0.04), shear rate (p = 0.02) and FVC (p = 0.03), compared to participants without DS.
Thessa I.M. Hilgenkamp、Sang Ouk Wee Elizabeth C. Schroeder、Tracy Baynard、Bo Femhall
展开 >
Integrative Physiology Laboratory, Department of Kinesiology and Nutrition, University of Illinois
NSTL
