首页|Association of serum paraoxonase activity with (ipid profile, APO-A and APO-B in subjects with different levels of HDL
Association of serum paraoxonase activity with (ipid profile, APO-A and APO-B in subjects with different levels of HDL
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Coronary heart diseases are inversely related to plasma high-density lipoprotein (HDL) level. Paraoxonase-1 (PON1) is mainly associated with HDL and plays a vital role in protection of low-density lipoprotein (LDL) and HDL. The aim of this study was to investigate the association between paraoxonase activity (PON1) with lipid profile, apoA-I, apoB and apoB/apoA-I ratio in subjects with different level of HDL cholesterol (HDL-C). Methods: 135 subjects, 20—60 years old, contributed to this study. The subjects were divided into three groups (45 in each group) with different levels of HDL-C (High, Normal and Low). For each group, the activity of PON1 was measured using paraoxon as a substrate. Moreover, the serum level of lipid profile, ApoA and apoB were measured. The statistical analysis was performed using SPSS software.
Maryam Teimouri、Hashem Nayeri
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Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran