Vitiello, AntonioPorta, Raffaele LaFerrara, Francesco
6页
查看更多>>摘要：On March 11， 2020 the World Health Organization (WHO) declared the state of global pandemic caused by the new SARS-CoV-2 (COVID-19)。 To date， no antivirals directed against SARS-CoV-2 or effective vaccines to combat the viral infection are available。 Severe acute respiratory syndrome caused by SARS-CoV-2 is treated empirically with antivirals， anti-inflammatory， anticoagulants。 The approval of an effective vaccine still takes time。 In this state， it may be useful to find new therapeutic solutions from drugs already on the market。 Recent hypotheses suggest that the use of AT-1 receptor antagonists (ARB) in combination with neprilisin inhibitors (NEPi) could indirectly provide clinical benefits to patients with SARS-CoV-2 and cardiac involvement。 In this article we investigate and describe a possible innovative pharmacological approach for the treatment of the most severe stages of COVID-19 infection。
Vavougios, George D.Ntoskas, Konstantinos T.Doskas, Triantafyllos K.
3页
查看更多>>摘要：Coagulopathy has recently been recognized as a recurring complication of COVID-19， most typically associated with critical illness。 There are epidemiological， mechanistic and transcriptomic evidence that link Selenium with SARS-CoV-2's intracellular latency。 Taking into consideration the vital role of selenoproteins in maintaining an adequate immune response， endothelial homeostasis and a non-prothrombotic platelet activation status， we propose that impairment in selenocysteine synthesis， via perturbations in the aforementioned physiological functions， potentially constitutes a mechanism of coagulopathy in COVID 19 patients other than those developed in critical illness。
查看更多>>摘要：Corona Virus Disease 2019 (COVID-19) has emerged as a pandemic leading to unprecedented disruption of global health and economy。 Transmembrane protease serine 2 (TMPRSS2) has been found to be critical in priming the viral spike protein and the host ACE2 receptor before the virus enters into the host cell。 Recent studies have experimentally demonstrated that Alpha 1 antitrypsin (encoded by SERPINA1 gene) is an inhibitor of TMPRSS2 and provided support to the already approved therapy as a candidate for COVID-19。 Interestingly Alpha 1 antitrypsin deficiency is common among Europeans。 Here we have provided in silico evidence that Alpha 1 antitrypsin can interact with TMPRSS2 and both of them are co-expressed in the human liver and lung。 We then analyzed the gnomAD dataset to show that Europeans and Latinos have a substantially higher carrier frequency of Alpha 1 Antitrypsin Deficiency (similar to 12%) compared to other large ethnicities。 Therefore， we hypothesize that Alpha 1 antitrypsin deficiency might be a risk factor for severe infection with SARS-CoV-2。 We propose Alpha 1 antitrypsin status as a potential prognostic predictor of COVID-19 outcome。
查看更多>>摘要：The disease presentation of primary hyperparathyroidism (PHPT) is more severe in children。 We hypothesize that this difference in disease presentation is a result of several factors including a delay in diagnosis， age-related differences in calcium metabolism and bone turnover， and the influence of the growth hormone (GH)/insulin growth factor-1 (IGF-1) axis。 Only the first two explanations for the heightened disease severity of PHPT in children have been previously discussed in the literature。 In regards to the potential role GH and IGF-1 may play in this disparity， previous studies have documented decreases in GH and IGF-1 secretion in symptomatic adult PHPT patients potentially influencing the severity of the patients' disease presentation。 While these studies have yet to be replicated in the pediatric population， given that both GH and IGF-1 are important for the achievement of peak bone mass in young individuals， it is logical to infer that the GH/IGF-1 axis may be partly responsible for the severe presentation of PHPT in children。
Morchiladze, Mariam M.Silagadze, Tamila K.Silagadze, Zurab K.
4页
查看更多>>摘要：Several studies point to the antimicrobial effects of ELF electromagnetic fields。 Such fields have accompanied life from the very beginning， and it is possible that they played a significant role in its emergence and evolution。 However， the literature on the biological effects of ELF electromagnetic fields is controversial， and we still lack an understanding of the complex mechanisms that make such effects， observed in many experiments， possible。 The Covid-19 pandemic has shown how fragile we are in the face of powerful processes operating in the biosphere。 We believe that understanding the role of ELF electromagnetic fields in regulating the biosphere is important in our fight against Covid-19， and research in this direction should be intensified。
查看更多>>摘要：Background: Bipolar disorder type I is a severe psychiatric condition that leads to significant morbidity and mortality and whose treatment remains suboptimal。 Its pathophysiology involves disturbance in the control of ionic fluxes so that when patients are either manic or depressed， the resting membrane potential of neurons is more depolarized than normal。 Available mood stabilizers have a shared mechanism of normalizing ion flux by compensating for ionic abnormalities， and normalizing membrane potential。
NSTL
Elsevier