查看更多>>摘要：Piper lanatum belongs to the Piperaceae family and is locally known as chabai hutan or akar kalong in Malaysia.It is traditionally used to treat malaria,toothache,rheumatism,deworming,fever,influenza,and ulcers[1].We have recently reported on the chemical compositions and biological activities of the essential oil from this species[2].The GC and GC-MS analysis of P.lanatum essential oil resulted in the identification of 39 components(78.2%),and the major components identified were borneol(7.5%),β-caryophyllene(6.6%),and a-amorphene(5.6%).In another study,it was shown that the leaf oil contains chavibetol(42,7%)as the major component[3].The oil also showed strong antimicrobial activity towards Aspergillus niger with a minimum inhibitory concentration value of 62.5 μg/mL[2].In addition,the leaf extract showed weak inhibitory activities towards mushroom tyrosinase and cholinesterase enzymes[1].As part of our continuing search to explore novel natural compounds from Piper species[4-6],we have conducted a phytochemical study of the aerial parts of P.lanatum.Fractionation and purification of the extracts afforded five amides,N-isobutyl-(2E,4E)-tetradecadienamide(1),N-isobutyl-(2E,4E,14Z)-eicosat-rienamide(2),N-isobutyl-15-(3',4'-methylene-dioxyphenyl)-2E,4E,12Z-pentadecatrienamide(3),N-p-coumaroyltyramine(4),trans-N-p-feruloyltyramine(5),together with sesamin(6),β-sitosterol(7),β-sitostenone(8),lupenone(9),and taraxerone(10).Their structures were established on the basis of spectroscopic analysis and chemical evidence.To the best of our knowledge,all compounds were isolated for the first time from this species.
NETL
NSTL