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Fitoterapia
Inverni della Beffa SpA
Fitoterapia

Inverni della Beffa SpA

0367-326X

Fitoterapia/Journal FitoterapiaSCIISTP
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    Pratensein attenuates A beta-induced cognitive deficits in rats: Enhancement of synaptic plasticity and cholinergic function (vol 101, pg 208, 2015)

    Wei, LingLv, ShujuanHuang, QuanfangWei, Jinbin...
    1页
      原文链接:
    • NSTL
    • Elsevier

    Tabernaecorymine A, an 18-normonoterpenoid indole alkaloid with antibacterial activity from Tabernaemontana corymbosa

    Fan, KunZhang, Lan-ChunHu, Wei-YanDeng, Shi-Yu...
    6页
    查看更多>>摘要：Tabernaecorymine A, an 18-normonoterpenoid indole alkaloid with conjugated (E)-3-aminoacrylaldehyde fragment was obtained from the stem bark of Tabernaemontana corymbosa. Its structure was elucidated by extensive spectroscopic data analyses, and further verified by ACD/structure elucidator, electronic circular dichroism (ECD) analyses and density functional theory (DFT) chemical shift predictions. The compound exhibited significant antibacterial bioactivity against Streptococcus dysgalactiae with an MIC value of 3.12 mu g/mL, which is better than the plant drug berberine.
      原文链接:
    • NSTL
    • Elsevier

    p New anti-influenza A viral norsesquiterpenoids isolated from feces-residing Streptomyces sp

    Lu, ShengshengXie, XiHu, JiananLin, Haixing...
    8页
    查看更多>>摘要：Three novel norsesquiterpenoids, (2R,4S,8aR)-8,8a,1,2,3,4-hexahydro-2-hydroxy-4,8a-dimethyl-2(2H)-naphthalenone (1), (1S,3S,4S,4aS,8aR)-4,8a-dimethyloctahydronaphthalene-1,3,4a(3H)-triol(2), (4S,4aS,8aS)-octahydro-4a-hydroxy-4, 8a-dimethyl-1(2H)-naphthalenone (3), as well as six other known analogues (4-9), were isolated from the culture broth of Streptomyces sp. XM17, an actinobacterial strain inhabiting the fresh feces of the giant panda Ailuropoda melanoleuca. The chemical structures of 1-3 were elucidated comprehensively by NMR spectroscopic and MS analyses, furthermore, the stereochemical configurations were resolved by NOESY experiments, along with ECD spectral and single-crystal X-ray crystallographic analyses. These compounds were then tested for their antiviral activities using the "pretreatment of virus" approach, which showed that most of these compounds were potent in inhibiting the entry of influenza A virus, with IC50 values ranging from 5 to 49 nM and selectivity indices all above 500.
      原文链接:
    • NSTL
    • Elsevier

    Biologically active polyphenolic compounds from Lespedeza bicolor

    Tarbeeva, Darya, VKrylova, Natalya, VIunikhina, Olga, VLikhatskaya, Galina N....
    8页
    查看更多>>摘要：We investigated the ability of six prenylated premcarpans, stilbenoid, and a new dimeric flavonoid, lespebicolin B, from stem bark as well as two 3-O-rutinosides and a mixture of 3-O-beta-D-glucosides of quercetin and kaempferol from flowers of Lespedeza bicolor to inhibit HSV-1 replication in Vero cells. Pretreatment of HSV-1 with polyphenolic compounds (direct virucidal effect) showed that pterocarpans lespedezol A(2) (1), (6aR,11aR)-6a,11a-dihydrolespedezol A(2) (2), (6aR,11aR)-2-isoprenyldihydrolespedezol A(2) (4), and (6aR,11aR,3'R)-dihy-drolespedezol A(3) (5) significantly inhibited viral replication, with a selective index (SI) >= 10. Compound 4 possessed the lowest 50% - inhibiting concentration (IC50) and the highest SI values (2.6 mu M and 27.9, respectively) in this test. (6aR,11aR)-2-Isoprenyldihydrolespedezol A(2) (4) also had a moderate effect under simultaneous treatment of Vero cells with the tested compound and virus (IC50 and SI values were 5.86 mu M and 12.4, respectively). 3-O-rutinosides of quercetin and kaempfeml and a mixture of 3-O-beta-D-glucosides of quercetin and kaempferol (10 and 12) also showed significant virucidal activity, with SI values of 12.5, 14.6, and 98.2, respectively, and IC50 values of 8.6, 12.2, and 3.6, respectively. We also performed a quantitative structure-activity relationship (QSAR) analysis of data on the virucidal activity of polyphenolics with 4 < pIC(50) < 6. It was found that the virucidal activity of these compounds depended on both the structure of the aromatic part and the conformation of geranyl and isoprenyl side chains of their molecules. These findings are correlated with the largest value of the principal moment of inertia (pmi) descriptor describing the geometry of molecules.
      原文链接:
    • NSTL
    • Elsevier

    Identification of limonoids from Walsura yunnanensis and evaluation of their cytotoxicity against cancer cell lines

    Zhao, YueqinYang, XuFei, JiminDong, Xianxiang...
    6页
    查看更多>>摘要：Three new limonoids, walsurauias A-C (1-3), along with four known ones, were isolated from the leaves and twigs of Walsura yunnanensis C. Y. Wu. Their structures were determined on the basis of comprehensive spectroscopic data analysis. The new limonoids were screened for their cytotoxic activity (IC50 0.81-5.73 mu M) against four human cancer cell lines, including A549, HepG2, HCT116 p21KO and CNE-2. And alpha,beta-unsaturated ketone moieties in rings A and B are essential for their cytotoxic activity. Selected compounds were further investigated. Compounds 1-3 effectively induced G2/M cell cycle arrest and apoptosis in a dose-dependent manner in cancer cells. In addition, compounds 1-3 inhibited the colony formation and compounds 2 and 3 suppressed the migration of cancer cells.
      原文链接:
    • NSTL
    • Elsevier

    Six new secoiridoid glycosides from the stem barks of Syringa Reticulata (Bl.) Hara

    Liu, YanZhu, Hui-ChenGuo, ShuangLiu, Pei...
    9页
    查看更多>>摘要：Six new secoiridoids, syrretosides E-J (1-6) and four known secoiridoids (7-10), were isolated from the stem barks of Syringa reticulata. Their structures were established by the 1D and 2D NMR spectra, HR-ESI-MS, and comparison with the literature. The cytotoxicity of the isolated monomeric compounds against RAW264.7 cells was investigated by the CCK8 assay, and the results showed that the individual compounds were not cytotoxic to RAW264.7. The anti-inflammatory activity of these compounds was evaluated using the LPS-induced RAW264.7 inflammatory cell model and the results showed that compounds 3-7 and 9 showed varying degrees of anti-inflammatory activity.
      原文链接:
    • NSTL
    • Elsevier

    p Extraction, purification, structural character and biological properties of propolis flavonoids: A review

    Cui, JingDuan, XueqinKe, LitingPan, Xingxue...
    26页
    查看更多>>摘要：Propolis is an aromatic substance which is collected by bees and mixed with bee saliva. The plant sources of propolis are mainly consisted with plant exudates from bark, buds and etc. Flavonoids are secondary metabolites widely found in natural plants, which have a variety of health care functions and are the main active ingredients of propolis. This article summarized the types, active ingredients, pharmacological effects, extraction methods and applications of propolis flavonoids, the aim was to provide the theoretical basis for further research and development of propolis flavonoids.
      原文链接:
    • NSTL
    • Elsevier

    New iridal-type triterpenoid analogues with 6/5/6-fused carbon skeleton from the rhizomes of Belamcanda chinensis

    Li, JiayuanNi, GangLiu, YanfeiWang, Renzhong...
    7页
    查看更多>>摘要：Five new iridal-type triterpenoid derivatives with 6/5/6 tricyclic ring skeleton (1-5) were obtained from the rhizomes of Belamcanda chinensis. Their structures were determined on the basis of detailed spectroscopic data and ECD calculation. Compounds 1-5 possessed the same 6/5/6-fused carbon skeleton as Belamchinenin A, which further enriched this kind of iridals. In vitro bioassay, compounds 2 and 3 exhibited 51.95 and 54.52% inhibitory activities, respectively, against Fe2+/cysteine-induced liver microsomal lipid peroxidation at a concentration of 10 mu M. A putative biogenetic pathway for compounds 1-5 was proposed.
      原文链接:
    • NSTL
    • Elsevier

    Commikuanoids A-C: New cycloartane triterpenoids with exploration of carbonic anhydrase-II inhibition from the resins of Commiphora kua by in vitro and in silico molecular docking

    Rehman, Najeeb UrHalim, Sobia AhsanKhan, AjmalKhan, Majid...
    7页
    查看更多>>摘要：Three new cycloartane triterpenoids, commikuanoids A-C (1-3), together with four known compounds 4-7, were isolated from the resin of Commiphora kua. Their structures were confirmed by advanced NMR techniques such as 1D (H-1 and C-13) and 2D (HMBC, HSQC, COSY, NOESY and NOE) and high-resolution mass spectrometry (HRMS). Five compounds (1-5) were screened for in vitro carbonic anhydrase II (CA II) inhibitory activity. All the tested compounds demonstrated significant activity against CA II with IC50 values ranging from 4.9-19.6 mu M. Moreover, the binding pattern of each compound in the binding site of CA-II was predicted through in silico molecular docking approach. It was observed that compounds 2, 4, and 5 binds with the Zn ion present in the active site of CA II, while compounds 1 and 3 mediated hydrogen bonding with Thr199 of CA-II, and all the compounds showed good binding score (> - 5 kcal/mol).
      原文链接:
    • NSTL
    • Elsevier