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Phytochemistry Letters
Elsevier B.V.
Phytochemistry Letters

Elsevier B.V.

1874-3900

Phytochemistry Letters/Journal Phytochemistry LettersSCIISTP
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    Carboline derivatives based on natural pityriacitrin as potential antifungal agents

    Min Y.Wang K.Yang J.Cao C....
    6页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeCarboline alkaloids are a class of important heterocyclic natural products, which usually present extensive bioactivities. During the course of our research for active compounds from natural products, the pityriacitrin and pityriacitrin B belonged carboline alkaloids have been isolated from a Chinese Burkholderia sp. NBF227, which indicated potential antifungal activities. So, in order to develop these carboline alkaloids as potential fungicidal agents, a series of pityriacitrin derivatives were investigated for their antifungal activities against Phytophthora capsici, Sclerotinia sclerotiorum, Botrytis cinerea and Rhizoctonia solani, and the results demonstrated that compounds 4, 10 and 19 displayed broad-spectrum antifungal activities. In addition, in vivo bioassay also indicated that compounds 4 and 10 could protect the pepper leaves and grape fruits against infection by P. capsici and B. cinerea, respectively. The possible mechanism of antifungal action for these compounds was also explored.
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    • NSTL
    • Elsevier

    New C9-polyacetylenes from the essential oil of the highly endangered species Baccharis palustris Heering (Asteraceae)

    Dellacassa E.Gonzalez A.Catalan C.A.N.Minteguiaga M....
    8页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeThe essential oil composition of the aerial parts from Baccharis palustris Heering (Asteraceae), a highly endangered species, was analyzed by GC/qMS, GC/HRMS-TOF, FT-IR, UV–vis and NMR spectroscopy using 1D and 2D techniques. To our knowledge, this is the first report on the essential oil composition of B. palustris, as well as the first phytochemical study on this plant species. The volatile extracts were obtained from different phenologicals stages of plant, at flowering stage (FS) and vegetative stage (VS), where 51 components were identified accounting for 96.3 % and 99.0 % of the oil, respectively. The oil was rich in polyacetylene compounds (> 75 %), being the main components identified the new natural C9-polyacetylenes 1-nonene-3,5-diyne (1, here named as baccharisdiyne) (52.7–65.0 %), 1,7(Z)-nonadiene-3,5-diyne [2, 7(Z)-dehydro-baccharisdiyne] (14.4–17.8 %), and 1,7(E)-nonadiene-3,5-diyne [3, 7(E)-dehydro-baccharisdiyne] (1.5–2.4 %). In addition, the known polyacetylenic compounds (Z)-lachnophyllum acid methyl ester (4) (4.3–5.3 %) and (E)-lachnophyllum acid methyl ester (5) (0.2 %) were also identified. Moreover, GC/qMS analysis allowed the identification of other 46 components in the essential oil samples, mainly mono- and sesquiterpenoids. In B. palustris, C9-polyacetylenes probably derive biogenetically from a C10 precursor: baccharisdiyne (1) would be derived from either or both lachnophyllum methyl ester geometric isomers (4 or 5), by enzymatic hydrolysis followed by decarboxylation. Dehydro-baccharisdiynes (2 and 3) could be produced by a similar pathway starting from the corresponding matricaria acid methyl ester isomers, one of which was tentatively identified at trace-level in B. palustris essential oil.
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    • NSTL
    • Elsevier

    Two new metabolites from Portulaca oleracea and their anti-inflammatory activities

    Tian J.Lan X.Ying X.Ying Z....
    6页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwo new metabolites, identified as 6-phenylbenzofuran-4-ol, named olerabenzofuran (1), and 2-(furan-2-yl)? 6-hydroxy-1 H-inden-1-one, named oleraindenone (2), together with eight furan compounds obtained for the first time, (+)-pinoresinol (3), (-)-syringaresinol (4), (+)-diasyringaresinol (5), (+)-episyringaresinol (6), (2 S)? 1-[2-(furan-2-yl)? 2-oxoethyl]? 5-oxopyrrolidine-2-carboxylic acid (7), methyl (2 S)? 1[2-(furan-2-yl)? 2-oxoethyl]? 5-oxopyrrolidine-2-carboxylate (8), drynaran (9), and 2-furoic acid (10), were isolated from Portulaca oleracea L., and spectroscopic methods, including 1D and 2D NMR and UHPLC-ESI-QTOF/MS spectrometry techniques, were employed to determine their structures. It was suggested that both olerabenzofuran (1) and oleraindenone (2) could significantly inhibit inflammatory factor interleukin-1β (IL-1β) in RAW 264.7 cells induced by LPS.
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    • NSTL
    • Elsevier

    Aucubin suppresses lipopolysaccharide-induced pro-inflammatory responses by blocking the NF-κB translocation signaling pathways in activated microglial cells

    Park Y.J.Lim J.Y.Kwon S.-H.Shin M.-S....
    8页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeAucubin is an iridoid glycoside with demonstrable hepatoprotective and anti-osteoporotic effects. Herein, using microglial cells and lipopolysaccharide (LPS) to induce inflammatory responses, we studied the signaling pathways involved in the anti-inflammatory action of aucubin and their influence on the expression of several genes known to be involved in inflammation. Aucubin inhibited LPS-stimulated pro-inflammatory responses by suppressing the production of nitric oxide and prostaglandin E2. Furthermore, aucubin inhibited inducible nitric oxide synthase and cyclooxygenase-2 at both the protein and mRNA levels. In addition, aucubin inhibited pro-inflammatory cytokine production in LPS-stimulated BV-2 microglial cells. Subsequent mechanistic studies revealed that aucubin inhibited the LPS-induced activation of nuclear factor-kappa B (NF-κB) translocation and phosphorylation of phosphatidylinositol 3-kinases (PI3K)/Akt as well as of mitogen-activated protein kinases (MAPKs), which are upstream molecules responsible for controlling inflammatory reactions. These results suggest that aucubin may exert anti-neuroinflammatory responses by suppressing the LPS-induced expression of pro-inflammatory mediators by blocking the activation of NF-κB, PI3K/Akt, and MAPK signaling pathways in microglial cells.
      原文链接:
    • NSTL
    • Elsevier

    Three new succinate-phenolic conjugates from the fruits of Actinidia arguta

    Ryu S.H.Lee S.Turk A.Hwang B.Y....
    4页
    查看更多>>摘要：? 2022 Phytochemical Society of EuropeThe fruit of Actinidia arguta, also called kiwiberry or hardy kiwifruit has cold-resistant characteristics with diverse biological activities. In this study, investigations was carried out to characterize the bioactive constituents of A. arguta for the elucidation of its health beneficial properties. Three new succinate conjugated phenolic glycosides, namely argutinosides J–L (1-3) were isolated from the fruits of A. arguta. The structures were determined on the basis of combined spectroscopic analysis by IR, UV, HRESIMS, 1D and 2D NMR spectral analysis. Compounds 1 and 2 showed mild DPPH radical scavenging activity by 52.1 % and 68.2 %, respectively, at the concentration of 500 μM whereas compound 3 showed weak activity.
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    • NSTL
    • Elsevier

    Corrigendum to “A new phenylethyl glycoside and a new dibenzocyclooctadiene lignan from the leaves of Kadsura coccinea (Lem.) A. C. Smith” [Phytochem. Lett. 45 (2021) 57–62] (Phytochemistry Letters (2021) 45 (57–62), (S1874390021001609), (10.1016/j.phytol.2021.07.012))

    Tram L.H.Huong T.T.Thuy L.T.Thong N.V....
    6页
    查看更多>>摘要：? 2021 Phytochemical Society of EuropeA new phenylethyl glycoside (1), (S)-1-phenylethyl-6-α-L-arabinopyranosyl-β-D-glucopyranoside), and a new dibenzocyclooctadiene lignan (7), Kasuracin A, together with seven known compounds, were isolated and identified from the leaves of Kadsura coccinea. Their structures were determined by analysis of multinuclear and multidimensional nuclear magnetic resonance (NMR), circular dichroism (CD), mass spectrometry, hydrolysis analysis, or comparison to those reported in the literature. Then, all the isolates 1?9 were evaluated for their inhibitory e?; ects against nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Among them, compounds 2 and 3 were isolated for the first time from this plant and compounds 3, 7, 8, and 9 significantly inhibited NO production with IC50 values of 36.4, 10.2, 12.3, and 21.7 μM, respectively.
      原文链接:
    • NSTL
    • Elsevier

    Corrigendum to “Bioactive pentacyclic triterpenes from the root extract of Ampelopsis japonica (Thunb.) Makino” [Phytochem. Lett. 45 (2021) 68–71, WOS: 000729961300013, IDS: XO1OB] (Phytochemistry Letters (2021) 45 (68–71), (S1874390021001671), (10.1016/j.phytol.2021.07.017))

    Niu C.Zhang Z.-Z.Yang L.-P.Zhai Y.-Y....
    1页
    查看更多>>摘要：? 2021 Phytochemical Society of EuropeThe authors regret that the printed version of the above article contained a number of errors, i.e., The first author name in the retrieved article is Makino Chao, Niu by Web of Science, however, the first author name should be Chao Niu. The authors would like to apologise for any inconvenience caused. The correct and final version is as follows: The correct author's name is Chao Niu a,1, Hui Wang b,1, Zhen-Zhen Zhang a, Lan-Ping Yang a, Yang-Yang Zhai a, Zhi-Qiang Liu a, Zhen-Zhen Liu a, Bao-Bao Zhang a, Jing-Chun Zhou c, Zhen-Hui Wang a, * In my article, the wrong author's name is Makino Chao, Niu a,1, Hui Wang b,1, Zhen-Zhen Zhang a, Lan-Ping Yang a, Yang-Yang Zhai a, Zhi-Qiang Liu a, Zhen-Zhen Liu a, Bao-Bao Zhang a, Jing-Chun Zhou c, Zhen-Hui Wang a, *
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    • NSTL
    • Elsevier

    Corrigendum to “A versatile tailoring tool for pentacyclic triterpenes of Penicillium griseofulvum CICC 40293” [Phytochem. Lett. 44 (2021) 195–201] (Phytochemistry Letters (2021) 44 (195–201), (S1874390021001373), (10.1016/j.phytol.2021.06.027))

    Zhu Y.Shen P.Zhou X.Fei Y....
    1页
    查看更多>>摘要：? 2021 Phytochemical Society of EuropeThe authors regret that the printed version of the above article contained a number of errors. The correct and final version follows. The authors would like to apologise for any inconvenience caused. Data in Table 2 in this Article had format problems and it had been corrected as follows. Table 2 Effect of the compounds on LPS-induced NO production in RAW 264.7 cellsa [Table presemted] a:Quercetin was used as a positive control. Values are mean±SD (n =3). b:Concentration necessary for 50 % inhibition (IC50). c:Effects showed no NO inhibition activity.
      原文链接:
    • NSTL
    • Elsevier