查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwo new ent-kaurane diterpenoids, namely 3α,16α-dihydroxy-ent-kauran-19-oic acid (1) and 3α,9β-dihydroxy-ent-kauran-19-oic acid (2), together with eight known compounds were isolated and identified from the leaves of Sphagneticola trilobata. Their structures were elucidated on the basis of extensive spectroscopic analysis including 1D, 2D NMR and MS techniques. Known compounds 4, 5 and 8?10 were obtained from S. trilobata for the first time. These compounds were tested for their in vitro α-glucosidase inhibitory activity and their tyrosinase inhibitory potential. Compounds 2, 3 and 6 were found to show in vitro α-glucosidase inhibitory activity with IC50 values ranging from 0.398 to 0.476 mM, which were close or more potent than reference compound acarbose (IC50 0.410 mM). Compounds 2 and 6 were further revealed to show in vitro tyrosinase inhibitory activity (IC50 29.25 and 40.74 μM) but inferior to that of the positive control kojic acid (IC50 12.55 μM).
查看更多>>摘要：? 2022 Phytochemical Society of EuropeSixteen eudesmane-type sesquiterpenes, including six unknown ones (1?6), were isolated from the aerial part of A. tournefortiana. NMR, HERIS-MS, IR spectra and ECD calculation assigned their relative and absolute configurations. Six (6, 7, 9, 13, 15, and 16) were tested for cytotoxic and anti-inflammatory activities, and seven (6, 7, 8, 12, 13, 15, and 16) were tested for antimicrobial activity. Among them, compound 15 showed significant cytotoxicity with IC50 values in the range of 1.49–5.30 μM and moderate antimicrobial activity.
查看更多>>摘要：? 2022The production of quince (Cydonia oblonga Miller) is affected worldwide by codling moth (Cydia pomonella L.), an oligophagous pest. In this study, volatile compounds in healthy and infested fruits were collected from four cultivars of quince: Champion, Portugal, Smyrna and INTA 147. Volatiles were extracted by SPME and analyzed by GC-MS. Up to 30 compounds were identified in the volatile profiles of uninfested quinces, ranging from 90.9% to 98.4% of the total relative abundance. The volatile profile of all four cultivars of quince was similar, with (E,E)-α-farnesene and octanoic acid- ethyl ester as the main components. Infested fruits presented increased levels of (E,E)-α-farnesene, while minor compounds decreased significantly. Champion and Smyrna varieties might be more susceptible cultivars to infestation as their healthy fruits presented the highest contents of (E,E)-α-farnesene and Pear Ester, both codling moth kairomones. The role of these highly recognized kairomones in the chemical ecology of codling moth in quince is discussed.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeThree new isoprenylated chromones, named harriforatins A?C (1?3), along with 13 known compounds (4?16) were isolated from the stems of Harrisonia perforata. Their planar structures were elucidated by spectroscopic measurements. The experimental and calculated ECD curves were used to determine their absolute configurations. Most isolated compounds were evaluated for inflammation inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Only compounds 5 and 6 showed inhibitory effects on NO production, with IC50 values of 42.8 and 47.0 μM, respectively, that were stronger than that of the positive control, indomethacin (IC50 = 68.6 μM).
查看更多>>摘要：? 2022 Phytochemical Society of EuropeA new secoiridoid (1) and a new xanthone glycoside (2), together with fourteen known compounds (3?16) were isolated from the dried whole plants of Lomatogonium rotatum (L.) Fries ex Nym. The chemical structures were elucidated based on extensive spectroscopic experiments, including 1D and 2D NMR as well as HR-ESI-MS, and comparison with those reported in the literature. All the compounds were evaluated for anti-complementary activity against the alternative pathways. Compounds 12 and 16 exhibited anti-complementary activity.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeSix undescribed bis-iridoids named Semipapposiridoids A–F (1–6) together with seventeen known compounds were obtained from the roots and aerial parts of Scabiosa semipapposa Salzm. ex DC. Among the known compounds, three lignans were isolated for the first time in Scabiosa species, whereas the other known constituents including iridoids, phenol glycosides and flavonoids were previously isolated from Scabiosa sp. Their structures were assigned on the basis of extensive 1D- and 2D NMR experiments (1H, 13C, COSY, TOCSY, NOESY, HSQC, HMBC), mass spectrometry HR-ESI-MS and by comparison of their spectral data with those of literature values. To the best of our knowledge, this should be the first report on the bis-iridoids content of this plant; furthermore, the fact that the plant is rich in mono-and bis-iridoids will support chemotaxonomy of the genus. The total phenolic and flavonoid contents of the 80% MeOH extracts and fractions were evaluated, with their antioxidant activities using three different methods, namely DPPH, ABTS and CUPRAC. Most of the fractions showed a moderate to good antioxidant activity compared to the standards BHA and BHT.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwo new acyl glycosides, angkorensides A and B (1 and 2) together with twelve known compounds including hedyotol C 7″-O-β-D-glucopyranoside (3), proanthocyanidin A-1 (4), (-)-epicatechin (5), (+)-lyoniresinol 3α-O-β-D-glucopyranoside (6), kaempferol-3-O-β-D-galactopyranoside (7), cuneataside E (8), 4-hydroxyacetophenone 4-O-(6′-O-β-D-apiofuranosyl)-β-D-glucopyranoside (9), cinnamtannin B-1 (10), aesculitannin B (11), quercetin 3-O-rham-(1?6)-β-D-galactopyranoside (12), quercetin 3-O-β-D-galactopyranoside (13), and proanthocyanidin A-2 (14) have been unprecedentedly isolated from Gardenia angkorensis Pit. Angkorensides A and B (1 and 2) showed moderate anti-inflammatory inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages and the known compounds (4, 10-14) exhibited strong 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity.
NSTL
Elsevier