查看更多>>摘要:By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News-New research on Oncology - Osteosarcom as is the subject of a report. According to news originating from Hunan, People' s Republic of China, by NewsRx correspondents, research stated, "Osteosarcoma is a primary malignant tumor that commonly affects children and adolescents, with a poor prognosis. The existence of tumor heterogeneity leads to different molecu lar subtypes and survival outcomes." Financial support for this research came from National Natural Science Foundatio n of China. Our news journalists obtained a quote from the research from Central South Unive rsity, "Recently, lipid metabolism has been identified as a critical characteris tic of cancer. Therefore, our study aims to identify osteosarcoma's lipid metabo lism molecular subtype and develop a signature for survival outcome prediction. Four multicenter cohorts-TARGET-OS, GSE21257, GSE39058, and GSE16091-were amalga mated into a unified Meta-Cohort. Through consensus clustering, novel molecular subtypes within Meta-Cohort patients were delineated. Subsequent feature selecti on processes, encompassing analyses of differentially expressed genes between su btypes, univariate Cox analysis, and StepAIC, were employed to pinpoint biomarke rs related to lipid metabolism in TARGET-OS. We selected the most effective algo rithm for constructing a Lipid Metabolism-Related Signature (LMRS) by utilizing four machine-learning algorithms reconfigured into ten unique combinations. This selection was based on achieving the highest concordance index (Cindex) in the test cohort of GSE21257, GSE39058, and GSE16091. We identified two distinct lip id metabolism molecular subtypes in osteosarcoma patients, C1 and C2, with signi ficantly different survival rates. C1 is characterized by increased cholesterol, fatty acid synthesis, and ketone metabolism. In contrast, C2 focuses on steroid hormone biosynthesis, arachidonic acid, and glycerolipid and linoleic acid meta bolism. Feature selection in the TARGET-OS identified 12 lipid metabolism genes, leading to a model predicting osteosarcoma patient survival. The LMRS, based on the 12 identified genes, consistently accurately predicted prognosis across TAR GET-OS, testing cohorts, and Meta-Cohort. Incorporating 12 published signatures, LMRS showed robust and significantly superior predictive capability."