查看更多>>摘要:By a News Reporter-Staff News Editor at Robotics & Machine Learning Daily News Daily News – New research on Oncology - Breast Canc er is the subject of a report. According to news reporting originating from Zhej iang, People’s Republic of China, by NewsRx correspondents, research stated, “Th e aim of this study was to predict gene signatures in breast cancer patients usi ng multiple machine learning models. In this study, we first collated and merged the datasets GSE54002 and GSE22820, obtaining a gene expression matrix comprisi ng 16,820 genes (including 593 breast cancer (BC) samples and 26 normal control (NC) samples).” Our news editors obtained a quote from the research from First Affiliated Hospit al, “Subsequently, we performed enrichment analyses using Gene Ontology (GO), Ky oto Encyclopedia of Genes and Genomes (KEGG), and Disease Ontology (DO). We iden tified 177 differentially expressed genes (DEGs), including 40 up-regulated and 137 down-regulated genes, through differential expression analysis. The GO enric hment results indicated that these genes are primarily involved in extracellular matrix organization, positive regulation of nervous system development, collage n-containing extracellular matrix, heparin binding, glycosaminoglycan binding, a nd Wnt protein binding, among others. KEGG enrichment analysis revealed that the DEGs were primarily associated with pathways such as focal adhesion, the PI3K-A kt signaling pathway, and human papillomavirus infection. DO enrichment analysis showed that the DEGs play a significant role in regulating diseases such as int estinal disorders, nephritis, and dermatitis. Further, through LASSO regression analysis and SVM-RFE algorithm analysis, we identified 9 key feature DEGs (CF-DE Gs): ANGPTL7, TSHZ2, SDPR, CLCA4, PAMR1, MME, CXCL2, ADAMTS5, and KIT. Additiona lly, ROC curve analysis demonstrated that these CF-DEGs serve as a reliable diag nostic index. Finally, using the CIBERSORT algorithm, we analyzed the infiltrati on of immune cells and the associations between CF-DEGs and immune cell infiltra tion across all samples.”