查看更多>>摘要：Hypertension significantly increases the risk of cardiovascular diseases and seriously affects people's health.The incidence of hypertension is rising rapidly in the world and hypertension has become a significant factor influencing the global average life expectancy.The diagnosis of hypertension is generally fulfilled by measuring diastolic and systolic blood pressure,but it is insufficient to differentiate essential hypertension from secondary hypertension,so it is crucial to identifying the cause of hypertension by detecting biomarkers in plasma.In clinical practice,five plasma biomarkers are utilized for diagnosing hypertension,and the detection tasks of a large number of cases have raised increasing demands for cost-effective,efficient,speedy,and diverse methods,which makes many traditional diagnostic technologies inadequate for meeting the needs of clinical diagnosis.The nanomaterial-based detection techniques have frequently attained the qualities of quick reaction,low cost,straightforward operation,high sensitivity,and strong specificity in recent years with the advancement of nanotechnology,so they have great potential for early and rapid diagnosis.In this review,we will introduce the characteristics and drawbacks of current clinical detection methods for hypertension screening,the principles and advancements of nanotechnology-based detection methods,as well as their potentials for clinical application.
查看更多>>摘要：Collecting green hydrogen(H2)from water splitting driven by renewable energy is a new competition to implement the construction of H2 energy industry and promote new economic growth for global governments.The common strategy to enhance the efficiency of H2 production is to reduce the potential of electrolytic cell that is the mainstream way to prepare efficient electrocatalysts.Layered double hydroxides(LDHs)are one of the most active electrocatalysts with adjustable active sites in contemporary research.In this review,we discuss the recent advanced progress of LDHs for hydrogen evolution reaction(HER)on cathode and oxygen evolution reaction(OER)or organic oxidation on anode and emphasize the influence of LDHs structure regulation in water electrolysis process(HER/OER)as well as the current development status of organic oxidation catalyzed by active oxygen species on anode.Finally,we propose the current challenges of LDHs in electrocatalysis and prospect their developing tendency and further application.
查看更多>>摘要：Layered double hydroxide(LDH)is regarded as an advanced platform material in catalysis and attracts vast attrition recently.As a kind of two-dimensional layered material,it exhibits great advantages including cation-tunability in layer,lattice limitation,topological transformation,ion exchange and intercalation characteristics.It also can be used as building blocks for composite catalytic materials.Over 100 years,a large number of works have been accomplished and researchers made great progress on investigating the LDH-based catalytic materials.In this review,we summarize representative achievements and significant progress in recent years,which mainly include constructing high entropy catalytic material,high dispersion/stability and interfacial supported catalytic material,composite catalytic materials and nano-reactor based on LDH.Furthermore,through collecting the excellent works,we conclude the future development potential of LDH and provide a perspective.
查看更多>>摘要：In this review,we delve into the intricate regulation of the tumor microenvironment(TME)under malignant conditions and explore the transformative potential of nanoscale metal-organic frameworks(nMOFs)in the realm of sonodynamic therapy(SDT).The THE serves as a dynamic milieu influencing tumor progression and therapeutic response,presenting formidable challenges,such as hypoxia,acidity,excess hydrogen peroxide,high expression of glutathione,and immunosuppression.Utilizing the exceptional attributes of nMOFs,including their tunable structures and biocompatibility,holds immense promise for enhancing SDT efficacy and reshaping the THE landscape.By integrating nMOFs with SDT,researchers aim to assemble multiple functionalities in a single platform that enhance tumor cell eradication while counteracting unfavorable THE conditions and immune resistance.The potential of nMOFs to revolutionize tumor therapies by precisely targeting THE and overcoming therapeutic barriers is underscored by an in-depth analysis of recent breakthroughs in the use of nMOFs-based sonosensitizers to remodulate THE to amplify the efficacy of SDT.
查看更多>>摘要：Carbon nanobelts(CNBs)with aesthetically appealing molecular structures and outstanding physical properties have attracted more and more attentions from the scientific community due to their potential applications in synthetic materials,host-guest chemistry,optoelectronics,and so on.The synthesis of CNBs at different stages was overviewed and some representative breakthroughs and advances in synthetic strategies were highlighted and discussed.The key issue for the synthesis of CNBs is how to construct curved structures with high strain energy.We not only proposed a few unconventional CNBs as the promising target molecules,but also pointed out the bottom-up synthesis of conjugated tubular segments of carbon nanotubes sharing similar properties as carbon nanotubes is the next focus in this emerging area.
查看更多>>摘要：Cyclic GMP-AMP(cGAMP)synthase(cGAS)plays a pivotal role in the innate immune system.As the primary DNA sensor in cells,cGAS binds to dsDNA in the cytoplasm and forms cGAS-DNA liquid-liquid phase separation(LLPS)and activates its catalytic activity.This activation triggers the cGAS-stimulator of interferon genes(STING)signaling pathway,establishing an efficient system for pathogen detection.Beyond pathogen surveillance,cGAS performs a diverse range of roles,involved in inflammatory response,metabolic homeostasis,DNA damage repair,and cell death.These biological functions regulate cellular physiological homeostasis and influence the occurrence and development of diseases.This review provides an overview of the structure,localization,and intracellular biological functions of the cGAS-STING signaling pathway and cGAS-DNA LLPS.Furthermore,we discuss their contribution to the development of tumors,autoimmune diseases,and inflammatory diseases and highlight the innovative strategies in modulating cGAS activity,either through activation or inhibition,as a promising therapeutic approach.
查看更多>>摘要：With the rapid development of industrialization,it is inevitable to produce solid wastes in the fields of energy petrochemical industry.However,the storage and utilization of these solid wastes have become a considerable challenge.Due to the main element composition of these solid wastes including silicon and aluminum,it has attracted extensive attention for synthesizing zeolites.This review summarized the properties of major solid wastes including coal fly ash,coal gangue,spent fluid catalytic cracking(FCC)catalyst,lithium slag,bauxite residue,and waste glass,Then,the preparation of LTA,FAU,ZSM-5,SSZ-13,Beta,and MOR zeolites from these solid wastes were introduced.Finally,the current challenges and perspectives were discussed.
查看更多>>摘要：Developing easily accessible deep-red/near-infrared circularly polarized emitters for practical organic light-emitting diodes remains a significant challenge.Here,a practical strategy has been proposed for developing deep-red circularly polarized delayed fluorescent emitters based on a novel chiral acceptor platform.By changing triphenylamine(TPA)substitution position from para to meta,R/S-M-TBBTCN demonstrated thermally activated delayed fluorescence(TADF)properties with a delayed lifetime of 6.6 ps that R/S-P-TBBTCN doesn't have.Furthermore,R/S-M-TBBTCN showed a 65 nm red-shift in emission and a 10-fold enhancement in asymmetry factor(glum),compared with R/S-P-TBBTCN.The solution-processed nondoped circularly polarized organic light-emitting diodes(CP-OLEDs)based on R-M-TBBTCN display deep-red emission and 2.2％external quantum efficiency.
LIU Yuan-YuanZHU Hao-LinLIAO Pei-QinCHEN Xiao-Ming...
664-669页
查看更多>>摘要：Driven by renewable or excess electrical energy,electrochemical CO2 reduction reaction(eCO2RR)represents a promising carbon-neutral approach to generating valuable low-carbon fuels by consuming CO2 and H2O.C2+products are one of the most economically valuable products among the reduction species of eCO2RR,but there are still some challenges,such as low selectivity or low current density.In this work,we showed that a copper-based metal-azolate framework(MAF),denoted as MAF-203,exhibits the high performance of eCO2RR to yield C2+products with the Faradaic efficiency(C2+)of 52.5％and a current density of 660 mA/cm2 at-1.2 V vs.RHE in a flow cell device under alkaline condition.Controlled experiment,in situ infrared spectroscopy and the density functional theory(DFT)calculations showed that the electron donating effect of methyl substituents on organic ligands of the copper-based MAF could enhance the ligand field and activation of key intermediates(*CO and*CHO species),thus promoting the coupling of*CO and*CHO for yielding C2+products.
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