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海南医科大学学报（英文版）
海南医科大学学报（英文版）

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海南医科大学学报（英文版）/Journal Journal of Hainan Medical University
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    Virological Characteristics and Prevention and Control of Omicron Sub-lineage BA.2

    Xiao-Wen YaoRong WangCai-Hong WangYu-Xia Zhou...
    1-6页
    查看更多>>摘要：The Omicron sub-lineage BA.2 has caused a new round of infection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), leading to a surge in the number of COVID-19 cases in many countries, including China. Because the subvariant BA.2 shows strong infectivity, fast transmission, strong immune escape ability, relatively mild symptoms, strong concealment, difficult to find and so on, it has gradually become a new challenge during the COVID-19 pandemic. Understanding the virological characteristics of Omicron sub-lineage BA.2 is of great significance for epidemic prevention and control. This paper briefly summarizes the virological characteristics and prevention and control strategies of Omicron sub-lineage BA.2.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Effect of Wei's triple nine needling therapy on flash visual evoked potentials in rats with traumatic optic neuropathy

    Shi-Meng LiJian ZhouQi-Ping WeiJun Wang...
    7-12页
    查看更多>>摘要：Objective: To investigate the effect of Wei's triple nine needling therapy on the N2-P2 wave of the flash visual evoked potential (FVEP) in rats of the of the transverse directional pulling model. Methods: Thirty-six Wistar rats were randomly grouped, nine were in normal control group without any treatment, and the remaining 27 were surgically modelled in the right eyes. Eighteen of these rats were randomly divided into a Wei's triple nine needling therapy group and a model group of nine rats each after the TON model was made using the transverse quantitative retraction method. The other 9 rats were sham-operated, and only the optic nerve was exposed without retraction. On the next day of modelling, the Wei's triple nine needling therapy group was treated with Wei's triple nine needling therapy for 20 minutes/1 time/1 day for 14 days. The model group, sham-operated group and normal control group were not intervened. Wei's triple nine acupoints were represented as follows: 1st link: "Jingming" (BL1) and " Chengqi" (ST1); 2nd link: "Sizhukong" (SJ23) penetrating "Taiyang" (EX-HN5); and the third: "Fengchi" (GB 20) and "Taichong" (LV3). The FVEP of each group was observed on 1d, 7d and 14d.The FVEP of each group was observed on 1d, 7d and 14d. Results: Compared with the model group, the N2 wave latency and P2 wave latency were shortened in the Wei's triple nine needling therapy on 1d (P < 0.05, P < 0.01); on 7d, their N2 wave latency was shortened (P < 0.01) and the N2-P2 wave amplitude was increased compared with the model group (P < 0.05); on 14d, their P2 wave latency was shortened (P < 0.05) and the N2-P2 wave amplitude was increased. There was no statistical difference in N2 wave latency, P2 wave latency and N2-P2 wave amplitude in the sham-operated group on 1d, 7d and 14d (P > 0.05). The delayed N2 and P2 wave latencies in the model group did not improve from 1d to 14d (P > 0.05) and the amplitude decreased throughout, showing a significant difference on 14d compared to 1d (P < 0.05). In contrast, the N2 wave latency in Wei's triple nine needling therapy group was not significantly different until 7d to 14d (P < 0.05); its P2 wave latency, although significantly delayed from 1d to 7d (P < 0.05), recovered on 14d and reached a level that was not statistically different from 1d and 7d (P > 0.05). There was also no significant decrease in N2-P2 wave amplitude between 1d and 14d in Wei's triple nine needling therapy group (P > 0.05). Conclusion: In this experiment, the TON rat model was successfully established by the transverse quantitative retraction method, and the treatment of TON rats with Wei's triple nine needling therapy reduced the P2 wave delay of the FVEP electrophysiological signal and increased the N2-P2 amplitude, which had a certain positive effect on the repair of optic nerve injury, probably related to its effect of improving the conduction function of the optic nerve and protecting the retinal ganglion cells that had not been degenerated and necrosed.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Preparation and characterization of hemihydrate calcium sulfate-calcium hydroxide composite bone repair materials

    Zheng-Dong GuoYang-Yang BianXiao-Qian LiuDong Wang...
    13-17页
    查看更多>>摘要：Objective: To prepare a bone repair material with certain mechanical strength and biological activity, this paper used calcium sulfate hemihydrate (CSH) powder compounded with calcium hydroxide (Ca(OH)2) powder to prepare a bone repair scaffold material for physicochemical property characterization and testing. Methods: The physical and chemical properties and characterization of the dried and cured bone repair materials were determined by Fourier infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and scanning electron microscopy;Universal material testing machine to determine the mechanical and mechanical strength of composite materials. Results: XRD showed that the structure of the composite material phase at 5％ concentration was calcium sulfate hemihydrate and calcium hydroxide after hydration. The FT-IR and XRD analyses were consistent. Scanning electron microscopy (SEM) results showed that calcium hydroxide was uniformly dispersed in the hemihydrate calcium sulfate material. 0％, 1％, 5％, and 10％ specimen groups had compressive strengths of 3.86±3.1, 5.27±1.28, 8.22±0.96, and 14.4±3.28 MPa. 10％ addition of calcium hydroxide significantly improved the mechanical strength of the composites, but also reduced the the porosity of the material. Conclusion: With the addition of calcium hydroxide, the CSH- Ca(OH)2 composite was improved in terms of mechanical material and is expected to be a new type of bone repair material.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Correlation between NF-κB/TNF-α pathway and atrial fibrillation

    Ning XuJun-Jie LengZhuo-Ya YaoBi Tang...
    18-22页
    查看更多>>摘要：Objective: To detect the levels of TNF-α and NF-κB in serum and NF-κB in peripheral blood lymphocytes of patients with atrial fibrillation.To investigate the regularity and significance of its changes in patients with atrial fibrillation. Methods: Patients with atrial fibrillation hospitalized in our hospital from January 2020 to December 2021 were selected, including paroxysmal AF group (PAF group, n=75) and non-paroxysmal AF group (nPAF group, n=60), and healthy subjects were selected as the control group (CON group, n=107). Routine examination and color doppler echocardiography were improved after admission. The expression levels of TNF-α and NF-κB in AF and CON groups were detected by ELISA. The expression of NF-κB in peripheral blood lymphocytes of AF and CON groups was detected by Western blot.To study the relationship between TNF-α, NF-κB and atrial fibrillation. Results: The levels of TNF-α and NF-κB in AF group were higher than those in CON group, and the differences were statistically significant (P<0.05). nPAF group was higher than PAF group, the difference was statistically significant (P < 0.05).The levels of TNF-α, NF-κB, LVEDD and LVEDV in PAF group were higher than those in CON group, but lower than those in nPAF group, the difference was statistically significant (P < 0.05). The levels of LVEF and FS in PAF group were lower than CON group, but higher than nPAF group, with statistical significance (P < 0.05).Pearson analysis showed that TNF-α, NF-κB were positively correlated with LVEDD and LVEDV in atrial fibrillation group compared with normal group (P<0.05), was negatively correlated with LVEF and FS (P<0.01).Conclusion: The levels of TNF-α and NF-κB in serum and NF-κB in peripheral blood lymphocytes were significantly increased in patients with atrial fibrillation. The occurrence and development of atrial fibrillation were related to NF-κB and TNF-α.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Clinical study on the correlation between plasma lipopolysaccharide and the structural characteristics of coronary intravascular ultrasound plaques

    Meng-Xian HuGui-Xin HeDong-Mei YuanWei-Bin Qin...
    23页
    查看更多>>摘要：Objective: To study the correlation between plasma lipopolysaccharide and coronary atherosclerotic heart disease risk factors and plaque stability. Methods: 136 patients with unstable angina pectoris who underwent coronary angiography and intravascular ultrasound were selected from the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine. According to the results of IVUS, they were divided into stable plaques (stable plaques, SP) group of 72 patients With 64 cases in the Unstable plaques (UP) group, venous blood was drawn from the two groups of patients for blood lipid and lipopolysaccharide index detection, and the general baseline data of the two groups were recorded; the structural characteristics of the intravascular ultrasound plaques in the two groups were analyzed. To study the influencing factors of unstable plaques, the correlation between lipopolysaccharide and plaque structural characteristics, and the diagnostic efficacy of unstable plaques. Results: The expression levels of cholesterol, low-density lipoprotein, and LPS in the UP group were higher than those in the SP group (P<0.05), and the high-density lipoprotein expression levels were lower than those in the SP group (P=0.035); and the intravascular ultrasound structure of the plaque was UP The lipid pool area, the ratio of lipid pool to plaque area, the plaque eccentricity index, and the maximum plaque thickness of the group were higher than those of the SP group (P<0.05), and the minimum plaque thickness was smaller than that of the SP group and the difference was statistically significant (P<0.05); LPS was positively correlated with cholesterol, low-density lipoprotein, lipid pool area, ratio of lipid pool to plaque area, plaque eccentricity index, and maximum plaque thickness by Pearson correlation test (P<0.05) , Is negatively correlated with high-density lipoprotein (P=0.021); LPS is a risk factor for coronary plaque stability, and HDL is a protective factor for coronary plaque stability by binary logistic regression test. The difference is statistically significant Scientific significance (P=0.049, P=0.002); LPS diagnosis of coronary atherosclerotic plaque stability ROC area under the curve (AUC) is 0.889, 95％ CI is (0.805, 0.974), the best diagnosis point is 57.485 mg /L, the sensitivity is 80.60％, and the specificity is 73.70％. Conclusion: Plasma lipopolysaccharide is a risk factor of unstable plaque, which has certain diagnostic value for coronary artery plaque, and can be used as a quantitative diagnostic index of plaque vulnerability.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Construction and validation of prognostic model of hepatocellular carcinoma based on epigenetic factors

    Hai-Hang ZhangJiang-Zheng ZengXu ZhuHua-Mao Sun...
    24-30页
    查看更多>>摘要：Objective: To explore the targeting relationship between miRNA and epigenetic factors related to the prognosis of hepatocellular carcinoma (HCC), and to identify the potential impact of miRNA targeted epigenetic factors on the prognosis of HCC. Methods: The mRNA and miRNA sequencing data of all HCC samples were downloaded from the tumor Genome Atlas (TCGA) database, and the R program was used to analyze the difference of the sequencing data. The data of survival time, survival status and differential expression of miRNA were combined, and the risk score model of miRNA was constructed by univariate and multivariate Cox regression. The miRNA target genes and all the corresponding Epigenetic factors were predicted, and the differentially expressed Epigenetic factors (DEEFs) were screened.Then, the regulatory network of miRNA targeting deefs was established, the apparent factors in the network were enriched and analyzed, and the core genes in the protein-protein interaction (PPI) network and selection network were constructed. Finally, the relationship between the apparent factors and the prognosis of patients was analyzed and verified by Kaplan Meier (K-M) method. Results: 305 differentially expressed miRNAs were identified using EDGE algorithm. After Cox analysis, hsa-miR-139-5p, hsa-miR-101-3p and hsa-miR-7-5p (miR-139-5p, miR-101-3p and miR-7-5p) were finally screened as the Overall survival of HCC patients (Overall survival,OS). In addition, 34 DEEFs targeted by miRNAs were identified, among which EZH2, PKM, HJURP and CHEK1 had a significant impact on the survival of hepatocellular carcinoma. Conclusion: In this study, we successfully established a prognostic model of hepatocellular carcinoma miRNA-targeted epigenetics, and screened out epigenetic factors that are significantly related to the prognosis of hepatocellular carcinoma. It provides new potential prognostic biomarkers and therapeutic targets for HCC treatment, and lays a theoretical foundation for the follow-up basic research of HCC.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Effectiveness of Shengmai Injection on angina pectoris based on real-world propensity score method

    Zong-Liang YuChun-Quan SunFu-Mei LiuLong-Tao Liu...
    31-38页
    查看更多>>摘要：Objective: Shengmai injection is a commonly used traditional Chinese medicine for the treatment of angina pectoris. However, there is still a lack of high-quality clinical research evidence for the treatment effect of Shengmai injection for angina pectoris. Real-world studies based on large samples can provide Shengmai injection. Researches on the treatment of angina pectoris with Shengmai injection provide important evidence. Methods: This article is based on the information collected by the hospital information system (HIS) database of 22 tertiary A general hospitals for all patients who used Shengmai injection and those who did not use Shengmai injection. The propensity scoring method was used to evaluate the possible existence of the research data. The confounding factors are controlled. Through the general Logistic regression analysis method, the propensity score weighted Logistic regression analysis method and the propensity score weighted Logistic regression analysis method with covariates, the therapeutic effect of Shengmai injection on angina pectoris was explored. Results: Three kinds of logistic regression analysis showed that there were statistical differences in the treatment effect of Shengmai injection on angina pectoris in the group without Shengmai injection. Propensity score weighted logistic regression analysis with covariates balanced the effect of multiple confounding factors. Using real-world data to construct a retrospective cohort study confirmed the clinical effectiveness of Shengmai injection in the treatment of angina pectoris, and at the same time confirmed the wide application of Shengmai injection in angina pectoris complicated with multiple organ failure. Conclusion: Shengmai injection is effective in the treatment of angina pectoris. The weighted method of propensity score removes confounding factors, which improves the reliability of real-world research results.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Risk factors for infection with multidrug-resistant organisms in diabetic foot ulcer patients: A systematic review and meta-analysis

    Dong ChenXin-Bang LiuBai Chang
    39-45页
    查看更多>>摘要：Objective: To systematically evaluate the risk factors for multidrug-resistant organisms (MDROs) infection in patients with diabetic foot ulcer(DFU). Methods: The quality assessment of outcome measures was performed by searching the Web of Science, Embase library, PubMed, Cochrane Library databases and screening the literature on the risk factors of MDROs infection in DFU patients according to the inclusion and exclusion criteria, and meta-analysis was performed using revman5.3 analysis software. Results: 13 literature was retrieved, involving in 1715 patients. A total of 15 risk factors were included in the analysis and the meta-analysis showed that Previous hospitalization(OR=2.61,95％CI[1.51,4.52],P=0 .0006), Previous antibiotic use(OR=2.17,95％CI[1.24-3.78],P<0.01), Type of diabetes(OR=2.44,95％CI[1.29-4.63],P<0.01), Nature of ulcer(OR=2.16,95％CI[1.06-4.40],P=0.03), Size of ulcer(OR=2.56,95％CI[1.53-4.28],P<0.01), Osteomyelitis(OR=3.50,95％CI[2.37-5.17],P<0.01), Peripheral vascular disease(OR=2.37,95％CI[1.41-3.99],P<0.01),and Surgical treatment(OR=4.81,95％CI[2.95-7.84],P<0.01)were closely associated with MDROs infection in DFU patients. Conclusions: The risk factors of MDROs infection in patients with DFU were previous hospitalization, previous antibiotic use, type of diabetes, nature of ulcer, size of ulcer, osteomyelitis, peripheral vascular disease, and surgical treatment. This study is conducive to early detection of MDROs infection in high-risk groups and timely comprehensive treatment to delay the development of the disease.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Research on anti-pancreatic cancer mechanism of Codonopsis codonopsis based on network pharmacology

    Xiao-Qing XuYa-Ping YuBing-Shu WangYong-Hao Fan...
    46-52页
    查看更多>>摘要：Objective: The mechanism of Dangshen (Codonopsis pilosula) in treating pancreatic cancer (PC) was explored by network pharmacology technology and platform. Methods: The traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP) was used to collect the effective compounds and potential targets of C.pilosula , and the genes associated with PC were obtained through the GeneCards database, the interaction genes between the effective compound targets of C.pilosula and PC targets were explored by the Venny method. The following mapping the interaction genes into a protein–protein interaction (PPI) network, and the key targets were screened. Finally, the interactive genes were imported into the DAVID database for gene ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) signal enrichment. Results: Twenty-one effective compounds and 98 downstream target genes of C.pilosula were screened through the TCMSP database. A total of 1,278 PC target genes were obtained through the GeneCards database, and the number of overlap genes between C.pilosula targets and PC related genes was 54, of which 10 were key node genes, namely CASP3, TP53, MDM2, AKT1, ESR1, BCL2L1, MCL1, HSP90AA1, CASP9, and CCND. These interactive genes involved a total of 30 typical GO terms and 20 KEGG signals. Conclusion: C. pilosula may play a role in treating PC through multi-component, multi-target, and multi-signal pathways.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Research advances of Chinese and Western medicine in the treatment of unexplained recurrent spontaneous abortion

    Yun-Qing QuXiao-Ling FengZhi-Yu Han
    53-58页
    查看更多>>摘要：Recurrent spontaneous abortion is a common disease in gynecology, and it seriously affects women's reproductive health and brings heavy burden and pain to society and families. The cause of recurrent spontaneous abortion is complicated, in addition to the well-defined genetic, anatomical, infection and endocrine factors, and there are still some unknown causes, which is called as unexplained recurrent spontaneous abortion, accounting for 40％ of recurrent abortion. At present, there are a lot of researches on the treatment methods of the patients with the unexplained recurrent spontaneous abortion, which also shows that the treatment of traditional Chinese and Western medicine all have certain clinical application effect. Western medicine clinical methods mainly includes immunotherapy, immunosuppressive therapy, anticoagulation therapy, progesterone therapy, etc. Based on the experience of the professor and combined with many years of clinical practice, the author believes that the pathogenesis of this disease in traditional Chinese medicine is mainly due to impaired impulse and deficiency of Spleen, lack of qi and blood,can not nourishing the fetus; deficiency of Kidney Qi, blood flow was delayed, and blood stasis and could not raise the fetus. Clinical treatment is based on invigorating the kidney, tonifying spleen and nourishing blood, promoting blood circulation to remove blood stasis and dredging collaterals. Oral Chinese medicine combined with external acupuncture and moxibustion has achieved excellent effects in improving pregnancy rate. This article reviews the domestic and foreign methods of treating unexplained recurrent miscarriage in order to provide clinical reference. In the future, the combination of Chinese and Western medicine should become the main therapy to increase pregnancy rate.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普