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中医科学杂志（英文）
北京中医药大学、清华大学出版社有限公司
中医科学杂志（英文）

北京中医药大学、清华大学出版社有限公司

季刊

2095-7548

bucmjtcms@163.ccom

010-64286200

100029

北京市朝阳区北三环东路11号

中医科学杂志（英文）/Journal Journal of Traditional Chinese Medical Sciences
查看更多>>《中医科学杂志（英文）》是中医药领域的同行评审杂志，创刊于2014年7月，由教育部主管，北京中医药大学和清华大学出版社联合主办，国际出版集团Elsevier负责在线出版和开放获取,北京中医药大学校长徐安龙教授担任主编。本杂志致力于搭建最具权威性的英文平台，向国际输出最前沿、最严谨的中医药研究成果，传播各国中医药政策及相关产业发展的信息，反映当今世界中医药研究最高水准。杂志主要收录原创研究类文章，内容覆盖中医、中药、针灸领域，包括各种基础和临床研究，以及综述、政策新闻和病例报告。
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    Treating acute low back pain with acupuncture:A randomized controlled study protocol to compare the effectiveness between distal and local acupoints

    Singleung ChanShukyan LamSinyin HoWanyi Au...
    351-356页
    查看更多>>摘要：Objective:To compare the efficacy of using"distal acupoints only"vs."local acupoints mainly combined with distal acupoints"in cases of acute low back pain(ALBP).Methods:A total of 102 eligible patients aged 18-65 years with ALBP lasting less than 6 weeks will be randomized in a 1∶1 ratio to the distal acupoints only group(DPOG)and the local acupoints mainly combined with the distal acupoints group(LPMG).During a 4-week treatment period,patients in the DPOG will receive acupuncture at distal acupoints only(Houxi[SI 3]and Yaotongxue[EX-UE 7])twice a week,while those in the LPMG group will receive acupuncture at local acupoints(mainly Shenshu[BL 23]and Dachangshu[BL 25])combined with distal points(Weizhong[BL 40]).The patients in both groups will be evaluated at every session of treatment,and the follow-up will be performed for 3 months.The primary outcome measure will be the change in ALBP intensity,assessed using visual analogue scale scores before and after treatment.The secondary outcome measure will be the evaluation of functional disability using the Oswestry Disability Index.Discussion:This study compares the DPOG and LPMG to explore the feasibility of the DPOG in the treatment of ALBP.
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    Electroacupuncture with different waveforms for primary dysmenorrhea:A randomized controlled trial

    Xiaona WuJingxue YuanJinxia NiXiuli Ma...
    357-362页
    查看更多>>摘要：Objective:To observe and compare the clinical effects of different electroacupuncture waveforms on primary dysmenorrhea.Methods:This was a prospective,randomized,three-group,parallel-controlled trial.Participants with primary dysmenorrhea were randomly divided into dense-sparse wave,continuous wave,and discon-tinuous wave groups in a 1i∶1∶1 ratio.Two lateral Ciliao(BL 32)points were used.All three groups started treatment 3-5 days before menstruation,once a day for six sessions per course of treatment,one course of treatment per menstrual cycle,and three menstrual cycles.The primary outcome measure was the proportion with an average visual analog scale(VAS)score reduction of ≥50％from baseline for dysmenorrhea in the third menstrual cycle during treatment.The secondary outcome measures included changes in dysmenorrhea VAS scores,Cox Menstrual Symptom Scale scores and the proportion of pa-tients taking analgesic drugs.Results:The proportion of cases where the average VAS score for dysmenorrhea decreased by ≥50％from baseline in the third menstrual cycle was not statistically significant(P＞.05).Precisely 30 min after acupuncture and regarding immediate analgesia on the most severe day of dysmenorrhea,there was a statistically significant difference in the dense-sparse wave group compared with the other two groups during the third menstrual cycle(P＜.05).Additionally,there was a statistically significant difference between the dense-sparse wave and discontinuous wave groups 24 h after acupuncture(P＜.05).Conclusions:Waveform electroacupuncture can alleviate primary dysmenorrhea and its related symp-toms in patients.The three groups showed similar results in terms of short-and long-term analgesic efficacy and a reduction in the number of patients taking analgesic drugs.Regarding achieving imme-diate analgesia,the dense-sparse wave group was slightly better than the other two groups.
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    Mechanism of acupoint penetration acupuncture therapy regulating chondrocyte autophagy via the PI3K/Akt-mTOR pathway in KOA rats

    Yang GaoQingbo WangSongwei LiXiaojing Shi...
    363-375页
    查看更多>>摘要：Objective:To investigate whether acupoint penetration acupuncture(APA)could regulate chondrocyte autophagy and apoptosis via the PI3K/Akt-mTOR signaling pathway to reduce cartilage degeneration in knee osteoarthritis(KOA)rats.Methods:KOA was induced in rats via intra-articular injection of sodium iodoacetate resolution.Forty male Sprague-Dawley rats were randomly assigned to blank control,model,APA,electro-acupuncture(EA),and sham model groups(n=8)and those in the APA and EA groups received their respective therapies.Following completion of the treatment course,histological examinations of cartilage and muscle were conducted.Levels of apoptosis-and autophagy-related factors,including Bax,Bcl-2,mTOR,ULK-1,and Beclin-1 protein,and mRNAs were assessed.Additionally,β-endorphin(β-EP)concentrations in the brain and serum were measured.Results:Histological analysis revealed that APA alleviated cartilage and muscle damage compared with the model group.APA inhibited cartilage degeneration by modulating the expression of apoptosis-and autophagy-related proteins and mRNA,thus preventing chondrocyte apoptosis.In the APA group,Bax and mTOR protein levels were significantly lower than those in the model group(both P=.024).Conversely,the Bcl-2 expression level was significantly higher than that in the EA group(P=.035).Additionally,ULK-1 expression was significantly lower than that in the EA group(P=.045).The mRNA level of Bax was significantly higher than that in the blank control group(P＜.001).However,Beclin-1 levels were significantly higher than those in both the model and EA groups(both P＜.001).ELISA results showed a significant decrease in the concentration of β-EP in the brains of the rats in the APA group compared with those in the model group(P=.032).Conclusions:APA reduced osteoarthritis-related pain and alleviated cartilage damage by upregulating chondrocyte autophagy and down-regulating apoptosis via signaling pathways involving PI3K/Akt-mTOR in KOA rats.
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    Acupotomy ameliorates knee osteoarthritis-related collagen deposition and fibrosis in rabbit skeletal muscle through the TGF-β/Smad pathway

    Tingyao HuEinar KhavazaChuxi LiangLongfei Xing...
    376-385页
    查看更多>>摘要：Objective:To investigate the effects of acupotomy on skeletal muscle fibrosis and collagen deposition in a rabbit knee osteoarthritis(KOA)model.Methods:Rabbits(n=18)were randomly divided into control,KOA,and KOA+acupotomy(Apo)groups(n=6).The rabbits in the KOA and Apo groups were modeled using the modified Videman's method for 6 weeks.After modeling,the Apo group was subjected to acupotomy once a week for 3 weeks on the vastus medialis,vastus lateralis,rectus femoris,biceps femoris,and anserine bursa tendons around the knee.The behavior of all animals was recorded,rectus femoris tissue was obtained,and histomorpho-logical changes were observed using Masson staining and transmission electron microscopy.The expression of transforming growth factor-β1(TGF-β1),Smad 3,Smad 7,fibrillar collagen types Ⅰ(Col-Ⅰ)and Ⅲ(Col-Ⅲ)was detected using Western blot and real-time polymerase chain reaction(RT-PCR).Results:Histological analysis revealed that acupotomy improved the microstructure and reduced the collagen volume fraction of rectus femoris,compared with the KOA group(P=.034).Acupotomy inhibited abnormal collagen deposition by modulating the expression of fibrosis-related proteins and mRNA,thus preventing skeletal muscle fibrosis.Western blot and RT-PCR analysis revealed that in the Apo group,Col-Ⅰ,and Col-Ⅲ protein levels were significantly lower than those in the KOA group(both P＜.01),same as Col-Ⅰ and Col-Ⅲ mRNA levels(P=.0031;P=.0046).Compared with the KOA group,the protein levels of TGF-β1 and Smad 3 were significantly reduced(both P＜.01),as were the mRNA levels of TGF-β1 and Smad 3(P=.0007;P=.0011).Conversely,the levels of protein and mRNA of Smad 7 were significantly higher than that in the KOA group(P＜.01;P=.0271).Conclusion:Acupotomy could alleviate skeletal muscle fibrosis and delay KOA progress by inhibiting collagen deposition through the TGF-β/Smad pathway in the skeletal muscle of KOA rabbits.
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    "中医体质辨识体系建立及应用"荣获国家科技进步奖二等奖

    北京中医药大学期刊中心
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