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世界胃肠病学杂志（英文版）
世界胃肠病学杂志（英文版）

潘伯荣

周刊

1007-9327

wjg@wjgnet.com

010-85381901-628

100025

北京市朝阳区东四环中路62号楼远洋国际中心D座903室

世界胃肠病学杂志（英文版）/Journal World Journal of GastroenterologyCSCDCSTPCDSCI
查看更多>>主要报道和刊登国内外、特别是我国消化病学者具有创造性的、有较高学术水平的基础和临床研究论文、研究快报等. 对具有中国特色的研究论文, 如食管癌、胃癌、肝癌、大肠癌、病毒性肝炎、幽门螺杆菌、中医中药、中西医结合和基于作者自己研究工作为主的综述性论文, 将优先发表. 读者对象为基础研究或临床研究的消化专业工作者。
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    Concomitant lung metastasis in patients with advanced hepatocellular carcinoma

    Tian YangJun-Hua LuChuan LinSong Shi...
    2533-2539页
    查看更多>>摘要：AIM:To investigate the clinical features and prognostic factors of advanced hepatocellular carcinoma (HCC) patients presenting with lung metastasis at initial diagnosis.METHODS:Between 2001 and 2010,we recruited 76consecutive HCC patients initially presenting with lung metastasis,without co-existing metastasis from other sites.These patients were divided into three groups:untreated group (n =22),single treatment group (n =19),and combined treatment group (n =35).RESULTS:Metastasis of bilateral lung lobes was common and noted in 35 patients (46.1％),and most of patients (59/76,77.6％) presented with multiple lung metastatic nodules.Nineteen patients (25.0％)received single-method treatment,including hepatectomy in 4,transcatheter arterial chemoembolization in 6,radiotherapy in 5,and oral sorafenib in 4.Thirty-five patients (46.1％) received combined treatment modalities.The overall median survival of the all patients was 8.7 ± 0.6 mo; 4.1 ± 0.3,6.3 ± 2.5 and 18.6 ± 3.9 mo,respectively in the untreated group,single treatment group and combined treatment group,respectively,with a significant difference (log-rank test,P ＜ 0.001).Multivariate analysis revealed that Child-Pugh score,the absence or presence of portal vein tumor thrombus,and treatment modality were three independent prognostic factors affecting survival of patients with advanced HCC and concomitant lung metastasis.CONCLUSION:Combined treatment modalities tend to result in a better survival as compared with the conservative treatment or single treatment modality for HCC patients initially presenting with lung metastasis.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Detection of eukaryotic translation initiation factor 4E and its clinical significance in hepatocellular carcinoma

    Xiao-Lin WangHong-Pei CaiJun-Hui GeXiao-Feng Su...
    2540-2544页
    查看更多>>摘要：AIM:To study the expression of eukaryotic translation initiation factor 4E (eIF4E),which is closely correlated with malignant tumors,and its relationship to prognosis in hepatocellular carcinoma.METHODS:Western blotting was performed to quantify the elF4E protein expression in the normal human liver cell line L02 and the hepatoma cell lines Hep3B,HepG2,and Huh7.Forty-six hepatocellular carcinoma samples with complete clinical data were obtained from Changzheng Hospital during the period of December 2008 to July 2009.The expression of eIF4E in the tumor samples and their adjacent tissues were detected by immunohistochemistry.The relationship between the test results and hepatocellular carcinoma (HCC)prognosis was statistically analysed by using a COX proportional hazard model.RESULTS:Western blotting analysis showed that there were distinct eIF4E protein bands in all three of the hepatoma cell lines.In particular,the HepG2 cell line had the highest level of eIF4E protein expression.The L02 cell group had a low eIF4E expression.Immunohistochemical assay showed that there were 32 cases in which the tumour tissue expression was higher than their adjacent tissues,accounting for 69.57％.There were also 14 cases in which the tumour tissue expression was lower or no significant difference was found,accounting for 30.43％.COX proportional hazards model analysis showed that HCC prognosis was related to the depth of invasion,the overexpression of eIF4E and p53,possibly as independent HCC prognostic predictors.CONCLUSION:In summary,eIF4E expression is associated with liver cancer,and patients with high eIF4E expression levels have a higher risk of recurrence.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Association between body mass index and erosive esophagitis: A meta-analysis

    Nan CaiGuo-Zhong JiZhi-Ning FanYan-Feng Wu...
    2545-2553页
    查看更多>>摘要：AIM:To conduct a meta-analysis to estimate the determinants of the association between erosive esophagitis (EE) and body mass index (BMI).METHODS:We identified the studies using PubMed.Studies were selected for analysis based on certain inclusion and exclusion criteria.Data were extracted from each study on the basis of predefined items.Metaanalyses were performed to verify the risk factors,such as obesity and gender.RESULTS:Twenty-one studies were included in this systematic review.These studies demonstrated an association between increasing BMI and the presence of EE [95％ confidence interval (CI):1.35-1.88,overweight,odds ratio (OR) =1.60,P value homogeneity 0.003,95％ CI:1.65-2.55,obese,OR =2.05,P ＜0.01].The heterogeneity disappeared by stratifying for gender.No publication bias was observed in this metaanalysis by the Egger method.CONCLUSION:This analysis demonstrates a positive association between BMI and the presence of EE,especially in males.The risk seems to progressively increase with increasing weight.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Serum inter-cellular adhesion molecule 1 is an early marker of diagnosis and prediction of severe acute pancreatitis

    Hai-Hang ZhuLin-Lin Jiang
    2554-2560页
    查看更多>>摘要：AIM:To determine if serum inter-cellular adhesion molecule 1 (ICAM-1) is an early marker of the diagnosis and prediction of severe acute pancreatitis (SAP)within 24 h of onset of pain,and to compare the sensitivity,specificity and prognostic value of this test with those of acute physiology and chronic health evaluation (APACHE) Ⅱ score and interleukin-6 (IL-6).METHODS:Patients with acute pancreatitis (AP) were divided into two groups according to the Ranson's criteria:mild acute pancreatitis (MAP) group and SAP group.Serum ICAM-1,APACHE Ⅱ and IL-6 levels were detected in all the patients.The sensitivity,specificity and prognostic value of the ICAM-1,APACHE Ⅱ score and IL-6 were evaluated.RESULTS:The ICAM-1 level in 36 patients with SAP within 24 h of onset of pain was increased and was significantly higher than that in the 50 patients with MAP and the 15 healthy volunteers (P ＜ 0.01).The ICAM-1 level (25 ng/mL) was chosen as the optimum cutoff to distinguish SAP from MAP,and the sensitivity,specificity,positive predictive value,negative predictive value (NPV),positive likelihood ratio and negative likelihood ratio were 61.11％,71.42％,0.6111,0.7142,2.1382 and 0.5445,respectively.The area under the curve demonstrated that the prognostic accuracy of ICAM-1 (0.712) was similar to the APACHE-Ⅱ scoring system (0.770) and superior to IL-6 (0.508) in distinguishing SAP from MAP.CONCLUSION:ICAM-1 test is a simple,rapid and reliable method in clinical practice.It is an early marker of diagnosis and prediction of SAP within the first 24 h after onset of pain or on admission.As it has a relatively low NPV and does not allow it to be a stand-alone test for the diagnosis of AP,other conventional diagnostic tests are required.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Prevalence of depressive and anxiety disorders in Chinese gastroenterological outpatients

    Xiao-Jing LiYan-Ling HeHong MaZhe-Ning Liu...
    2561-2568页
    查看更多>>摘要：AIM:To investigate the prevalence and physicians'detection rate of depressive and anxiety disorders in gastrointestinal (GI) outpatients across China.METHODS:A hospital-based cross-sectional survey was conducted in the GI outpatient departments of 13general hospitals.A total of 1995 GI outpatients were recruited and screened with the Hospital Anxiety and Depression Scale (HADS).The physicians of the GI departments performed routine clinical diagnosis and management without knowing the HADS score results.SubJects with HADS scores ≥ 8 were subsequently interviewed by psychiatrists using the Mini International Neuropsychiatric Interview (MINI) to make further diagnoses.RESULTS:There were 1059 patients with HADS score ≥ 8 and 674 (63.64％) of them undertook the MINI interview by psychiatrists.Based on the criteria of Diagnostic and Statistical Manual of Mental Disorders (4th edition),the adjusted current prevalence for depressive disorders,anxiety disorders,and comorbidity of both disorders in the GI outpatients was 14.39％,9.42％ and 4.66％,respectively.Prevalence of depressive disorders with suicidal problems [suicide attempt or suicide-related ideation prior or current; module C (suicide) of MINI score ≥ 1] was 5.84％ in women and 1.64％ in men.The GI physicians' detection rate of depressive and anxiety disorders accounted for 4.14％.CONCLUSION:While the prevalence of depressive and anxiety disorders is high in Chinese GI outpatients,the detection rate of depressive and anxiety disorders by physicians is low.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Evaluation of malignancy using Ki-67, p53, EGFR and COX-2 expressions in gastrointestinal stromal tumors

    Jing JiangMei-Shan JinJian SuoYin-Ping Wang...
    2569-2575页
    查看更多>>摘要：AIM:To investigate the role of expressions of Ki-67,p53,epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) in gastrointestinal stromal tumor (GIST) grading and prognosis.METHODS:Tumor tissue was collected retrospectively from 96 patients with GIST.Antibodies against Ki-67,p53,EGFR and COX-2 were used for immunohistochemical staining.Tumor grading was designated according to a consensus system and the staining was quantified in 3 categories for each antibody in the statistical analysis.RESULTS:The Ki-67 expression in GISTs was significantly associated with the size of the tumors,mitotic rate and the risk of malignancy (x2 =15.51,P =0.02;x2=22.27,P ＜ 0.001; x2=20.05; P ＜ 0.001).The p53 expression was also significantly correlated with mitotic rate and the risk of malignancy (x2 =9.92,P =0.04; x2 =9.97; P =0.04).Over-expression of Ki-67was strongly correlated with poor survival (x2 =10.44,P =0.006),but no correlation was found between the expression of p53,EGFR or COX-2 and survival.Multivariate analysis further demonstrated that Ki-67expression (relative risk =15.78,95％ CI:4.25-59.37)could be used as an independent prognostic value for GIST patients.Adjuvant imatinib therapy could improve clinical outcomes in the patients with high risk and intermediate risk of recurrence after complete tumor resections (median survival time:52 mo vs 37 mo,x2 =7.618,P =0.006).CONCLUSION:Our results indicated that the expression of Ki-67 could be used as an independent prognostic factor for GIST patients.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Effects of glycine on phagocytosis and secretion by Kupffer cells in vitro

    Hui-Wen WuKe-Ming YunDe-Wu HanRui-Ling Xu...
    2576-2581页
    查看更多>>摘要：AIM:To investigate the effects and mechanisms of action of glycine on phagocytosis and tumor necrosis factor (TNF)-α secretion by Kupffer cells in vitro.METHODS:Kupffer cells were isolated from normal rats by collagenase digestion and Percoll density gradient differential centrifugation.After culture for 24 h,Kupffer cells were incubated in fresh Dulbecco's Modification of Eagle's Medium containing glycine (G1:1 mmol/L,G2:10 mmol/L,G3:100 mmol/L and G4:300 mmol/L) for 3 h,then used to measure phagocytosis by a bead test,TNF-α secretion after lipopolysaccharide stimulation by radioactive immunoassay,and microfilament and microtubule expression by staining with phalloidin-fluorescein isothiocyanate (FITC) or a monoclonal anti-α tubulin-FITC antibody,respectively,and evaluated under a ultraviolet fluorescence microscope.RESULTS:Glycine decreased the phagocytosis of Kupffer cells at both 30 min and 60 min (P ＜ 0.01,P ＜0.05).The numbers of beads phagocytosed by Kupffer cells in 30 min were 16.9 ± 4.0 (control),9.6 ± 4.1 (G1),12.1 ± 5.7 (G2),8.1 ± 3.2 (G3) and 7.5 ± 2.0 (G4),and were 22.5 ± 7.9 (control),20.1 ± 5.8 (G1),19.3 ± 4.8 (G2),13.5 ± 4.7 (G3) and 9.2 ± 3.1 (G4) after 60 min.TNF-α secretion by Kupffer cells in G1 (0.19 ± 0.03),G2(0.16 ± 0.04),G3 (0.14 ± 0.03) and G4 (0.13 ± 0.05)was significantly less than that in controls (0.26 ± 0.03,P ＜ 0.01),and the decrease in secretion was dose-dependent (P ＜ 0.05).Microfilaments of Kupffer cells in G2,G3 and G4 groups were arranged in a disorderly manner.The fluorescence densities of microtubules in G1 (53.4±10.5),G2 (54.1 ± 14.6),G3 (64.9 ± 12.1) and G4 (52.1± 14.2) were all lower than those in the controls (102.2± 23.7,P ＜ 0.01),but the decrease in microtubule fluorescence density was not dose-dependant.CONCLUSION:Glycine can decrease the phagocytosis and secretion by Kupffer cells in vitro,which may be related to the changes in the expression of microfilaments and microtubules induced by Kupffer cells.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Exceptionally rare cause of a total stomach resection

    Jadwiga SnarskaKrzysztof JacynaJacek JaniszewskiDanuta Shafie...
    2582-2585页
    查看更多>>摘要：The first-ever case of a 54-year-old woman who overdosed on non-steroidal anti-inflammatory drugs in an attempt at suicide.Before that incident,she had not been treated for coexisting diseases such as rheumatoid arthritis or depression.At the time of admission to the General Surgery Department,the patient reported pains in the epigastric region with accompanying nausea and vomiting with mucous content as well as the inability to ingest food orally.Despite parenteral and enteral feeding,the patient exhibited a drop in body mass.The histopathologic examination of a sample taken from the stomach during gastroscopy showed some non-specific necrotic and inflammatory masses with granulation.Intraoperatively,a very small,infiltrated stomach with an initial section of duodenum was identified.A total stomach resection together with the reconstruction of digestive tract continuity was performed using the Roux-Y method.Histopathologic examination of the stomach revealed a deep,chronic and exacerbated inflammatory condition with an extensive ulceration over the entire length of the stomach,reaching up to the pylorus.Additionally,numerous lymphatic glands with inflammatory reaction changes were observed.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Lamivudine treatment enabling right hepatectomy for hepatocellular carcinoma in decompensated cirrhosis

    Koichi HondaMasataka SeikeShin-ichiro MaeharaKoichiro Tahara...
    2586-2590页
    查看更多>>摘要：A 69-year-old man was admitted to our hospital in October 2003,for further examination of two liver tumors.He was diagnosed with hepatocellular carcinoma (HCC)arising from decompensated hepatitis B virus (HBV)-related cirrhosis.Long-term lamivudine administration improved liver function dramatically despite repeated treatment for HCC.His Child-Pugh score was 9 points at start of lamivudine treatment,improving to 5 points after 1 year.His indocyanine green at 15 min after injection test score was 48％ before lamivudine treatment,improving to 22％ after 2 years and to 5％ after 4 years.Radiofrequency ablation controlled the HCC foci and maintained his liver function.In April 2009,abdominal computed tomography revealed a tumor thrombus in the right portal vein.Since his indocyanine green test results had improved to less than 10％,we performed a right hepatectomy,which was successful.To our knowledge,there have been no documented reports of patients undergoing successful right hepatectomy for HCC arising from decompensated cirrhosis.The findings observed in our patient indicate the importance of nucleoside analogs for treating HBV-related HCC.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

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      原文链接:
    • NETL
    • NSTL
    • 万方数据