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世界胃肠病学杂志（英文版）
世界胃肠病学杂志（英文版）

潘伯荣

周刊

1007-9327

wjg@wjgnet.com

010-85381901-628

100025

北京市朝阳区东四环中路62号楼远洋国际中心D座903室

世界胃肠病学杂志（英文版）/Journal World Journal of GastroenterologyCSCDCSTPCDSCI
查看更多>>主要报道和刊登国内外、特别是我国消化病学者具有创造性的、有较高学术水平的基础和临床研究论文、研究快报等. 对具有中国特色的研究论文, 如食管癌、胃癌、肝癌、大肠癌、病毒性肝炎、幽门螺杆菌、中医中药、中西医结合和基于作者自己研究工作为主的综述性论文, 将优先发表. 读者对象为基础研究或临床研究的消化专业工作者。
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    Investigation of compensatory postures with videofluoromanometry in dysphagia patients

    Antonio SolazzoLuigi MonacoLucia Del VecchioStefania Tamburrini...
    2973-2978页
    查看更多>>摘要：AIM:To investigate the effectiveness of head compensatory postures to ensure safe oropharyngeal transit.METHODS:A total of 321 dysphagia patients were enrolled and assessed with videofluoromanometry (VFM).The dysphagia patients were classified as follows:safe transit; penetration without aspiration; aspiration before,during or after swallowing; multiple aspirations and no transit.The patients with aspiration or no transit were tested with VFM to determine whether compensatory postures could correct their swallowing disorder.RESULTS:VFM revealed penetration without aspiration in 71 patients (22.1％); aspiration before swallowing in 17 patients (5.3％); aspiration during swallowing in 32 patients (10％); aspiration after swallowing in 21 patients (6.5％); multiple aspirations in six patients (1.9％); no transit in five patients (1.6％); and safe transit in 169 patients (52.6％).Compensatory postures guaranteed a safe transit in 66/75 (88％) patients with aspiration or no transit.A chin-down posture achieved a safe swallow in 42/75 (56％) patients,a head-turned posture in 19/75 (25.3％) and a hyperextended head posture in 5/75 (6.7％).The compensatory postures were not effective in 9/75 (12％) cases.CONCLUSION:VFM allows the speech-language therapist to choose the most effective compensatory posture without a trial-and-error process and check the effectiveness of the posture.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Diagnostic value for extrahepatic metastases of hepatocellular carcinoma in positron emission tomography/computed tomography scan

    Ji Eun LeeJae Young JangSoung Won JeongSae Hwan Lee...
    2979-2987页
    查看更多>>摘要：AIM:To evaluated the value of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) scan in diagnosis of hepatocellular carcinoma (HCC) and extrahepatic metastases.METHODS:A total of 138 patients with HCC who had both conventional imaging modalities and 18F-FDG PET/CT scan done between November 2006 and March 2011 were enrolled.Diagnostic value of each imaging modality for detection of extrahepatic metastases was evaluated.Clinical factors and tumor characteristics including PET imaging were analyzed as indicative factors for metastases by univariate and multivariate methods.RESULTS:The accuracy of chest CT was significantly superior compared with the accuracy of PET imaging for detecting lung metastases.The detection rate of metastatic pulmonary nodule ≥ 1 cm was 12/13(92.3％),when ＜ 1 cm was 2/10 (20％) in PET imaging.The accuracy of PET imaging was significantly superior compared with the accuracy of bone scan for detecting bone metastases.In multivariate analysis,increased tumor size (≥ 5 cm) (P =0.042) and increased average standardized uptake value (SUV)uptake (P =0.028) were predictive factors for extrahepatic metastases.Isometabolic HCC in PET imaging was inversely correlated in multivariate analysis (P =0.035).According to the receiver operating characteristic curve,the optimal cutoff of average SUV to predict extrahepatic metastases was 3.4.CONCLUSION:18F-FDG PET/CT scan is invaluable for detection of lung metastases larger than 1 cm and bone metastases.Primary HCC having larger than 5 cm and increased average SUV uptake more than 3.4should be considered for extrahepatic metastases.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Noninvasive assessment of hepatic fibrosis in Egyptian patients with chronic hepatitis C virus infection

    Shawky Abdelhamid FouadSerag EsmatDalia OmranLaila Rashid...
    2988-2994页
    查看更多>>摘要：AIM:To evaluate the accuracy of specific biochemical markers for the assessment of hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection.METHODS:One hundred and fifty-four patients with chronic HCV infection were included in this study; 124patients were non-cirrhotic,and 30 were cirrhotic.The following measurements were obtained in all patients:serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),albumin,total bilirubin,prothrombin time and concentration,complete blood count,hepatitis B surface antigen (HBsAg),HCVAb,HCV-RNA by quantitative polymerase chain reaction,abdominal ultrasound and ultrasonic-guided liver biopsy.The following ratios,scores and indices were calculated and compared with the results of the histopathological examination:AST/ALT ratio (AAR),age platelet index (API),AST to platelet ratio index (APRI),cirrhosis discriminating score (CDS),Pohl score,G(o)teborg University Cirrhosis Index (GUCI).RESULTS:AAR,APRI,API and GUCI demonstrated good diagnostic accuracy of liver cirrhosis (80.5％,79.2％,76.6％ and 80.5％,respectively); P values were:＜ 0.01,＜ 0.05,＜ 0.001 and ＜ 0.001,respectively.Among the studied parameters,AAR and GUCI gave the highest diagnostic accuracy (80.5％) with cutoff values of 1.2 and 1.5,respectively.APRI,API and GUCI were significantly correlated with the stage of fibrosis (P ＜ 0.001) and the grade of activity (P ＜0.001,＜ 0.001 and ＜ 0.005,respectively),while CDS only correlated significantly with the stage of fibrosis (P ＜ 0.001) and not with the degree of activity (P ＞0.05).In addition,we found significant correlations for the AAR,APRI,API,GUCI and Pohl score between the non-cirrhotic (F0,F1,F2,F3) and cirrhotic (F4) groups (P values:＜ 0.001,＜ 0.05,＜ 0.001,＜ 0.001 and ＜0.005,respectively; CDS did not demonstrate significant correlation (P ＞ 0.05).CONCLUSION:The use of AAR,APRI,API,GUCI and Pohl score measurements may decrease the need for liver biopsies in diagnosing cirrhosis,especially in Egypt,where resources are limited.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Overexpression of metastasis-associated in colon cancer 1 predicts a poor outcome of hepatitis B virus-related hepatocellular carcinoma

    Jian-Hui QuXiu-Juan ChangYin-Ying LuWen-Lin Bai...
    2995-3003页
    查看更多>>摘要：AIM:To investigate the intratumoral expression of metastasis-associated in colon cancer 1 (MACC1) and c-Met and determine their clinical values associated with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).METHODS:A retrospective study admitted three hundred fifty-four patients with HBV-related HCC.The expression and distribution of MACC1 and c-Met were assessed by quantitative real-time polymerase chain reaction and immunohistochemistry staining.Prognostic factors influencing survival,metastasis and recurrence were assessed.RESULTS:Intratumoral MACC1 level was found to be associated with HCC disease progression.Both median tumor-free survival (TFS) and overall survival (OS) were significantly shorter in the postoperative HCC patients with high intratumoral MACC1 expression,as compared to those with low intratumoral MACC1 levels (TFS:34 mo vs 48.0 mo,P ＜ 0.001; OS:40 mo vs 48 mo,P ＜ 0.01).Multivariable analysis indicated that high MACC1 expression or co-expression with c-Met were independent predictors for HCC clinic outcome (P ＜ 0.001).CONCLUSION:High intratumoral MACC1 expression can be associated with enhanced tumor progression and poor outcome of HBV-related HCC.MACC1 may serve as a prognostic biomarker for postoperative HCC.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Investigation of the effect of military stress on the prevalence of functional bowel disorders

    Xian-Zhao YuHai-Feng LiuZhen-Xue Sun
    3004-3007页
    查看更多>>摘要：AIM:To investigate the morbidity of functional bowel disorders (FBD) under military stress conditions in order to lay foundations for the prevention and treatment of this disease.METHODS:Four hundred and fifty-seven soldiers who were assigned to specified services and 471 soldiers who were assigned to routine services were enrolled using cluster sampling,with the latter as a control group.They were surveyed using the Rome Ⅲ FBD standard questionnaire.The FBD symptom questionnaire included FBD-related symptoms,severity,duration or attack time,and accompanying symptoms.RESULTS:The morbidity of the military stress group (14.6％) was significantly higher than in the control group (9.98％) (x2 =4.585,P ＜ 0.05).The incidence of smoking,abdominal pain and acid regurgitation (x2=4.761,P ＜ 0.05) as well as the ZUNG anxiety/depression scores (x2 =7.982,P ＜ 0.01) were also significantly higher in the military stress group compared with the control group.ZUNG anxiety (x2 =11.523,P＜ 0.01) and depression (x2 =5.149,P ＜ 0.05) scores were higher in the FBD group compared with the nonFBD group.The differences in the ZUNG self-rated anxiety and depression scales between the 2 groups were statistically significant (x2 =14.482,P ＜ 0.01 andx2 =6.176,P ＜ 0.05).CONCLUSION:The morbidity of FBD was higher under military stress conditions.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Ultrasound-guided microwave ablation for abdominal wall metastatic tumors: A preliminary study

    Cai QiXiao-Ling YuPing LiangZhi-Gang Cheng...
    3008-3014页
    查看更多>>摘要：AIM:To evaluate the feasibility,safety and efficacy of ultrasound-guided microwave (MW) ablation for abdominal wall metastatic tumors.METHODS:From August 2007 to December 2010,a total of 11 patients with 23 abdominal wall nodules (diameter 2.59 cm ±1.11 cm,range 1.3 cm to 5.0cm) were treated with MW ablation.One antenna was inserted into the center of tumors less than 1.7 cm,and multiple antennae were inserted simultaneously into tumors 1.7 cm or larger.A 21 gauge thermocouple was inserted near important organs which required protection (such as bowel or gallbladder) for real-timetemperature monitoring during MW ablation.Treatment outcome was observed by contrast-enhanced ultrasound and magnetic resonance imaging (MRI) [or computed tomography (CT)] during follow-up.RESULTS:MW ablation was well tolerated by all patients.Six patients with 11 nodules had 1 thermocouple inserted near important organs for real-time temperature monitoring and the maximum temperature was 56 ℃.Major complications included mild pain (54.5％),post-ablation fever (100％) and abdominal wall edema (25％).All 23 tumors (100％) in this group were completely ablated,and no residual tumor or local recurrence was observed at a median follow-up of 13 mo (range 1 to 32 mo).The ablation zone was well defined on contrast-enhanced imaging (contrast-enhanced CT,MRI and/or contrast-enhanced ultrasound)and gradually shrank with time.CONCLUSION:Ultrasound-guided MW ablation may be a feasible,safe and effective treatment for abdominal wall metastatic tumors in selected patients.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Analysis of risk factors for polypoid lesions of gallbladder among health examinees

    Hua-Li YangLei KongLi-Li HouHui-Fang Shen...
    3015-3019页
    查看更多>>摘要：AIM:To investigate the prevalence and risk factors of polypoid lesions of gallbladder (PLG) among the health examinees in the Shanghai region,China.METHODS:A total of 11 816 subjects who underwent health examinations in our hospital between August 2010 and February 2011 were analyzed retrospectively.Among them,there were 7174 men and 4642 women.PLG was diagnosed by the real-time ultrasonography.Those with the body mass index (BMI) ≥ 28 were considered to be obese.Blood biochemical indices were detected with the fully automatic biochemical analyzer and hepatitis B surface antigen (HBsAg) was tested by the automated enzyme immunoassay.The correlations between the prevalence of PLG and age,sex,BMI,serum cholesterol (T-Cho),triglycerides (TG),blood sugar,HBsAg,high-density lipoprotein (HDL-C),low-density lipoprotein (LDL-C),gallstone and fatty liver were investigated.After univariate analysis of 11 variables,stepwise logistic regression analysis was performed to explore the risk factors of PLG.RESULTS:There was a significant difference in sex,T-Cho,HBsAg,HDL-C,LDL-C and fatty liver between the PLG-positive group and the PLG-negative group (332/163 vs 6842/4479,P =0.003; 22/473 vs295/11 026,P =0.013; 92/403 vs 993/10 328,P =0.001; 47/448 vs 332/10 989,P =0.001; 32/463 vs 381/10 940,P =0.001; 83/412 vs 3260/8061,P =0.001).No significant difference was found in the age,BMI,TG,blood sugar and gallstone between the two groups (47.3 ± 26 vs 45.1 ± 33,P =0.173; 59/436vs 1097/10 224,P =0.102; 52/443 vs 982/10 339,P=0.158; 17/478 vs 295/11 026,P =0.26; 24/471 vs 395/10 926,P =0.109).Logistic regression analysis showed that the sex,HBsAg and HDL-C were independent risk factors for the development of PLG in a descending order of HDL-C ＞ HBsAg ＞ sex.CONCLUSION:In healthy people,the male gender,positive HBsAg,and low HDL-C confer higher risks of PLG development.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    WWOX induces apoptosis and inhibits proliferation of human hepatoma cell line SMMC-7721

    Ben-Shun HuJing-Wang TanGuo-Hua ZhuDan-Feng Wang...
    3020-3026页
    查看更多>>摘要：AIM:To investigate the effects of the WWOX gene on the human hepatic carcinoma cell line SMMC-7721.METHODS:Full-length WWOX cDNA was amplified from normal human liver tissues.Full-length cDNA was subcloned into pEGFP-N1,a eukaryotic expression vector.After introduction of the WWOX gene into cancer cells using liposomes,the WWOX protein level in the cells was detected through Western blotting.Cell growth rates were assessed by methyl thiazolyl tetrazolium (MTT) and colony formation assays.Cell cycle progression and cell apoptosis were measured by flow cytometry.The phosphorylated protein kinase B (AKT)and activated fragments of caspase-9 and caspase-3 were examined by Western blotting analysis.RESULTS:WWOX significantly inhibited cell proliferation,as evaluated by the MTT and colony formation assays.Cells transfected with WWOX showed significantly higher apoptosis ratios when compared with cells transfected with a mock plasmid,and overexpression of WWOX delayed cell cycle progression from G1 to S phase,as measured by flow cytometry.An increase in apoptosis was also indicated by a remarkable activation of caspase-9 and caspase-3 and a dephosphorylation of AKT (Thr308 and Ser473) measured with Western blotting analysis.CONCLUSION:Overexpression of WWOX induces apoptosis and inhibits proliferation of the human hepatic carcinoma cell line SMMC-7721.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Surgical resection of a solitary para-aortic lymph node metastasis from hepatocellular carcinoma

    Junji UedaHiroshi YoshidaYasuhiro MamadaNobuhiko Taniai...
    3027-3031页
    查看更多>>摘要：Lymph node (LN) metastases from hepatocellular carcinoma (HCC) are considered uncommon.We describe the surgical resection of a solitary para-aortic LN metastasis from HCC.A 65-year-old Japanese man with B-type liver cirrhosis was admitted for the evaluation of a liver tumor.He had already undergone radiofrequency ablation,transcatheter arterial chemoemboliza tion,and percutaneous ethanol injection therapy for HCC.Despite treatment,viable regions remained in segments 4 and 8.We performed a right paramedian sectionectomy with partial resection of the left paramedian section of the liver.Six months later,serum concentrations of alpha-fetoprotein (189 ng/mL) and PIVKA-2 (507 mAU/mL) increased.Enhanced computed tomography of the abdomen revealed a tumor (20 mm in diameter) on the right side of the abdominal aorta.Fluorine-18 fluorodeoxyglucose positron emission tomography revealed an increased standard uptake value.There was no evidence of recurrence in other regions.Esophagogastroduodenoscopy and colonoscopy revealed no malignant tumor in the gastrointestinal tract.Para-aortic LN metastasis from HCC was thus diagnosed.We performed lymphadenectomy.Histopathological examination revealed that the tumor was largely necrotic,with poorly differentiated HCC on its surface,which confirmed the suspected diagnosis.After 6 mo tumor marker levels were normal,with no evidence of recurrence.Our experience suggests that a solitary para-aortic LN metastasis from HCC can be treated surgically.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Effect of discounting on estimation of benefits determined by hepatitis C treatment

    Andrea MessoriValeria FaddaDario MarateaSabrina Trippoli...
    3032-3034页
    查看更多>>摘要：The combination of either boceprevir or telaprevir with ribavirin and interferon (triple therapy) has been shown to be more effective than ribavirin+interferon (dual therapy) for the treatment of genotype 1 hepatitis C.Since the benefit of these treatments takes place after years,simulation models are needed to predict long-term outcomes.In simulation models,the choice of different values of yearly discount rates (e.g.,6％,3.5％,2％,1.5％ or 0％) influences the results,but no studies have specifically addressed this issue.We examined this point by determining the long-term benefits under different conditions on the basis of standard modelling and using quality-adjusted life years (QALYs) to quantify the benefits.In our base case scenario,we compared the long-term benefit between patients given a treatment with a 40％ sustained virologic response (SVR) (dual therapy) and patients given a treatment with a 70％ SVR (triple therapy),and we then examined how these specific yearly discount rates influenced the incremental benefit.The gain between a 70％ SVR and a 40％ SVR decreased from 0.45 QALYs with a 0％ discount rate to 0.22 QALYs with a 6％discount rate (ratio between the two values =2.04).Testing the other discounting assumptions confirmed that the discount rate has a marked impact on the magnitude of the model-estimated incremental benefit.In conclusion,the results of our analysis can be helpful to better interpret cost-effectiveness studies evaluating new treatment for hepatitis C.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普